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IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils.
- D. Kurotaki, Michio Yamamoto, +10 authors T. Tamura
- Biology, Medicine
- Nature communications
- 19 September 2014
Irf8(-/-) haematopoietic progenitors not only bestows monocyte and DC differentiation potential upon mononuclear phagocytes but also restrains these progenitor from differentiating into neutrophils. Expand
Regulation of basophil and mast cell development by transcription factors.
- Haruka Sasaki, D. Kurotaki, T. Tamura
- Biology, Medicine
- Allergology international : official journal of…
- 1 April 2016
An overview of recent advances in understanding of how transcription factors regulate the development of basophils and mast cells is provided. Expand
Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.
It is demonstrated that interferon regulatory factor-8 (IRF8), a transcription factor essential for the development of several myeloid lineages, also regulates basophil and mast cell development and that GATA2, a transcription factors known to promote basophils and mast cells differentiation, acts downstream of IRF8. Expand
Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.
It is demonstrated thatIRF8 regulates chromatin at the lymphoid-primed multipotent progenitor (LMPP) stage to induce early commitment toward DCs, and early expression of the key transcription factor IRF8 changes chromatin states in otherwise multipotential progenitors, biasing their fate decision towardDCs. Expand
Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.
The results illustrate the dynamic process by which key transcription factors regulate enhancer formation and, therefore, direct future gene expression to achieve mononuclear phagocyte development. Expand
Transcriptional control of monocyte and macrophage development.
Interestingly, local environmental factors such as heme, retinoic acid and RANKL induce the expression and/or activation of tissue-specific transcription factors, thereby controlling transcriptional programs specific for the subpopulations, which appear to contribute to the determination of macrophage transcriptional identities. Expand
226: The transcription factor IRF8 is required for the development of basophils
It is shown that Interferon Regulatory Factor-8 is required for the development of the basophil lineage and a previously unrecognized role of IRF8 in granulocyte development is uncovered. Expand
A role of the transcription factor IRF8 in basophil and mast cell development
PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Transcription factor IRF 8 plays a critical role in the development of murine basophils and mast cells
Frontier Research Center, Osaka University, Osaka, Japan; Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National… Expand
Enhancer Landscape Dynamics and the Role of IRF8 in Mononuclear Phagocyte Development
It is found that a majority of monocyte- and DC-specific active enhancers were gradually established at progenitor stages prior to gene expression and terminal differentiation, and Computational DNA motif analysis implicated that these enhancer were regulated by combinations of lineage-determining transcription factors such as PU.1, RUNX, C/EBP, and IRF. Expand