Haruhiko Hoshino

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Thrombolytic therapy with intravenous tissue plasminogen activator (IV tPA) is initiated within 3 hours from the onset of ischemic stroke now. Following the publication of the results of ECASS III in 2008, IV tPA treatment has been initiated within 4.5 hours abroad. Expanding the therapeutic time window from 3 to 4.5 hours had been applied, but not approved(More)
The gliovascular complex (GVC) is a structural and functional unit located at the interface between the cerebral blood flow and neural network. Even though its physiological roles have been partially clarified, the contribution of the astroglia to maintenance of the cerebral vasculature, which is tightly wired with the neuronal network, is only incompletely(More)
To clarify the clinical features of moyamoya disease in Japan, 941 patients with definite moyamoya disease were analyzed from the databases constructed by the Research Committee on Moyamoya Disease, established by the Ministry of Health, Labour and Welfare. Moyamoya disease occurs much more frequently among women than men, with a female-to-male ratio of(More)
RATIONALE AND AIMS Monotherapy with antiplatelet agents is only modestly effective in secondary prevention of ischemic stroke (IS), particularly in patients with multiple risk factors such as cervicocephalic arterial stenosis, diabetes, and hypertension. While dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduced IS recurrence, particularly(More)
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. We appreciate the thorough commentary by Drs. Franks and Nettleton (1). The major finding of our paper (2) was that interaction between the cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(More)
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. We appreciate the thorough commentary by Drs. Franks and Nettleton (1). The major finding of our paper (2) was that interaction between the cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(More)
A 62-year-old man with diabetes mellitus, hypertension, and hyperlipidemia was admitted to our hospital because of sudden onset of left chest pain. He was diagnosed with unstable angina with left heart failure and underwent intra-aortic balloon pumping (IABP) immediately. On the 3rd day after removal of the IABP (7th hospital day), he developed sudden(More)
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