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- Barbara Carnemolla, Laura Borsi, +7 authors Luciano Zardi
- Blood
- 2002
Angiogenic processes depend on the precise coordination of different cell types and a complex exchange of signals, many of which derive from new specific components of the provisional,… (More)
- Laura Borsi, Enrica Balza, +10 authors Luciano Zardi
- Blood
- 2003
We sought to enhance the selective toxicity of tumor necrosis factor alpha (TNFalpha) to permit its systemic use in cancer therapy. Because ligand-targeted therapeutics have proven successful in… (More)
- Michele Moschetta, Francesca Pretto, +13 authors Raffaella Giavazzi
- Cancer research
- 2012
The selective delivery of bioactive agents to tumors reduces toxicity and enhances the efficacy of anticancer therapies. In this study, we show that the antibody F8, which recognizes perivascular and… (More)
- Oliver Driemel, Regine Dahse, +4 authors Hartwig Kosmehl
- Cytopathology : official journal of the British…
- 2007
BACKGROUND
The brush biopsy technique is not only a seminal technique but also a critically discussed method for detection of oral pre-cancerous stages and manifest carcinomas. The gamma2 chain of… (More)
- Cornelia Halin, Verena Gafner, +5 authors Dario Neri
- Cancer research
- 2003
The potent antitumor activity of certain cytokines is often achieved at the expense of unacceptable toxicity. One avenue to improve the therapeutic index of cytokines in cancer therapy consists of… (More)
- Cornelia Halin, Simona Rondini, +4 authors Dario Neri
- Nature Biotechnology
- 2002
Interleukin-12 (IL-12) is a heterodimeric cytokine with potent immunostimulatory activity and anti-angiogenic properties. Its clinical applications are limited, however, by severe side-effects. Here… (More)
- Dirk Ludewig, Hartwig Kosmehl, Manfred Sommer, Frank-D. Boehmer, Guenter Stein
- Cell and Tissue Research
- 1999
The current study was designed to investigate possible effects of the platelet-derived growth factor (PDGF) receptor kinase blocker AG1295 on the development of interstitial fibrosis in rats with… (More)
- Marcus Franz, Karin Spiegel, +9 authors Alexander Berndt
- Histochemistry and Cell Biology
- 2009
Snail is a regulator of epithelial–mesenchymal transition (EMT) and considered crucial to carcinoma metastasis, myofibroblast transdifferentiation, and fibroblast activation. To investigate the role… (More)
- Petra Richter, Claudia Umbreit, +6 authors Alexander Berndt
- Journal of oral pathology & medicine : official…
- 2011
Epithelial-mesenchymal transition (EMT) is suggested to be crucial for the development of an invasive and metastatic carcinoma cell phenotype. Therefore, the definition of this phenotype is of great… (More)
- Peter Hyckel, Alexander Berndt, +4 authors Hartwig Kosmehl
- Journal of cranio-maxillo-facial surgery…
- 2005
AIMS
The hereditary occurrence of cherubism indicates a probable genetic aetiology: a correlation with a mutation in the gene SH3BP2 has been demonstrated. A convincing concept of formal pathogenesis… (More)