Hartmut Michels

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OBJECTIVE To describe a registry set up to monitor children treated with etanercept in Germany and Austria. METHODS Giannini's criteria, duration of morning stiffness, number of swollen, tender and contracted joints, adverse events, and reasons for discontinuation were assessed. RESULTS 322 patients with juvenile idiopathic arthritis (JIA) and 12(More)
OBJECTIVE To describe the clinical and laboratory features of macrophage activation syndrome as a complication of juvenile systemic lupus erythematosus (SLE). METHODS Cases of juvenile SLE-associated macrophage activation syndrome were provided by investigators belonging to 3 pediatric rheumatology networks or were found in the literature. Patients who(More)
PURPOSE Chronic anterior uveitis in children often takes a serious course. Despite various immunosuppressive drugs some children do not respond sufficiently and there is a high risk of them becoming seriously disabled. Anti-TNF alpha therapy has been shown by our group and others to be mostly ineffective (Etanercept) or partly effective (Infliximab) with(More)
1. A new open-circuit respiration unit consisting of 6 respiration chambers, gas analysis unit and data-acquisition system is briefly described. 2. Energy and protein metabolism in broiler lines selected for improved food efficiency (FC) or for growth rate (GL) were measured weekly from 3 to 6 weeks of age. 3. Gross and apparent metabolisable energy intake(More)
We report the results of the cross-cultural adaptation and validation into the German language of the parent's version of two health related quality of life instruments. The Childhood Health Assessment Questionnaire (CHAQ) is a disease specific health instrument that measures functional ability in daily living activities in children with juvenile idiopathic(More)
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and adolescents. Immunomodulatory drugs are used frequently in its treatment. Using the nominal group technique (NGT) and Delphi method, we created a multidisciplinary, evidence- and consensus-based treatment guideline for JIA based on a systematic literature analysis and(More)
We determined the iron, zinc, selenium, rubidium, and cesium concentrations in serum and packed blood cells by instrumental neutron activation analysis without chemical separations. Lyophilized samples were irradiated for 12 days at a flux of 10(13) neutrons-cm-2-s-1, mineralized by wet digestion, and measured two times with a high-resolution Ge(Li)(More)
Fachdisziplinen angehören, mit teilweise jahrzehntelanger klinischer und wissenschaftlicher Erfahrung, und somit im fruchtbaren Diskurs der außerordentlichen Breite des Themas überhaupt gerecht werden konnten. Wichtige Aspekte der Leitlinien sollen hier kurz skizziert werden und einen Überblick über deren Inhalte verschaffen. Die Originalleitlinien mit der(More)