Harry van Loen

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BACKGROUND Benin has recently shifted its national antimalarial drug policy from monotherapies to combinations containing artemisinin derivatives. When this decision was taken, the available information on alternatives to chloroquine and sulphadoxine-pyrimethamine, the first- and second-line treatment, was sparse. METHODS In 2003 - 2005, before the drug(More)
Clinical malaria incidence was determined over 18 months in a cohort of 553 children living in a peri-urban area near Cotonou. Three cross-sectional surveys were also carried out. Malaria incidence showed a marked seasonal distribution with two peaks: the first corresponding to the long rainy season, and the second corresponding to the overflowing of Lake(More)
Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case–control study Unfortunately the original article [1] contained a typo in the title. Instead of " Diagnosis of neglected tropical diseases among patients with(More)
BACKGROUND Visceral leishmaniasis (VL) has become an important opportunistic infection in persons with HIV-infection in VL-endemic areas. The co-infection leads to profound immunosuppression and high rate of annual VL recurrence. This study assessed the effectiveness, safety and feasibility of monthly pentamidine infusions to prevent recurrence of VL in HIV(More)
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped(More)
BACKGROUND Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent(More)
Introduction Pharmaceutical research and development (R&D) historically neglected the infectious diseases that mainly or exclusively affect poor communities in low-and middle-income countries (LMICs) [1]. Recently, collaborative clinical research addressing the health needs of LMICs has become more frequent [2], including therapeutic and diagnostic trials(More)
SOP Title: Diagnostic sample flow (including techniques, handling and storage, preservation and shipment) Study title: Diagnosis of neglected tropical diseases (NTDs) in patients presenting with persistent digestive disorders (≥2 weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal. This SOP provides an overview on diagnostic procedures in the NIDIAG study on(More)
BACKGROUND Research is ongoing to develop multipurpose vaginal rings to be used continuously for contraception and to prevent Human Immunodeficiency Virus (HIV) infection. Contraceptive vaginal rings (CVRs) are available in a number of countries and are most of the time used intermittently i.e. three weeks out of a 4-week cycle. Efficacy trials with a(More)
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