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Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.

• C P Lebel, Harry Ischiropoulos, Stephen C Bondy
• Chemical research in toxicology
• 1992

The use of dichlorofluorescin (DCFH) as a measure of reactive oxygen species was studied in aqueous media. Hydrogen peroxide oxidized DCFH to fluorescent dichlorofluorescein (DCF), and the oxidation… (More)

Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells.

• James A Royall, Harry Ischiropoulos
• Archives of biochemistry and biophysics
• 1993

2',7'-Dichlorofluorescein and dihydrorhodamine 123 were evaluated as probes for detecting changes in intracellular H2O2 in cultured endothelial cells. Stable intracellular levels of these probes were… (More)

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

• Csaba Szabó, Harry Ischiropoulos, Rafael Radi
• Nature Reviews Drug Discovery
• 2007

Peroxynitrite — the product of the diffusion-controlled reaction of nitric oxide with superoxide radical — is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which… (More)

Peroxynitrite-mediated oxidation of dihydrorhodamine 123.

• Neil W. Kooy, John Royall, Harry Ischiropoulos, Joseph S. Beckman
• Free radical biology & medicine
• 1994

Nitric oxide reacts with superoxide to form peroxynitrite, which may be an important mediator of free radical-induced cellular injury. Oxidation of dihydrorhodamine to fluorescent rhodamine is a… (More)

Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.

• Harry Ischiropoulos
• Archives of biochemistry and biophysics
• 1998

Analytical and immunological methodologies and occasionally both methodologies have been applied to detect and quantify 3-nitrotyrosine in almost every major organ system. In certain diseases… (More)

Oxidative chemistry of peroxynitrite.

• Joseph S. Beckman, Jing Chun Chen, Harry Ischiropoulos, John P. Crow
• Methods in enzymology
• 1994

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

• D Christine Wu, Vernice R. Jackson-Lewis, +6 authors Serge E. Przedborski
• The Journal of neuroscience : the official…
• 2002

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages the nigrostriatal dopaminergic pathway as seen in Parkinson's disease (PD), a common neurodegenerative disorder with no effective… (More)

Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.

• Lemin Zheng, Benedicta N Nukuna, +11 authors Stanley L. Hazen
• The Journal of clinical investigation
• 2004

In recent studies we demonstrated that systemic levels of protein-bound nitrotyrosine (NO(2)Tyr) and myeloperoxidase (MPO), a protein that catalyzes generation of nitrating oxidants, serve as… (More)

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.

• Balaraman Kalyanaraman, Victor M. Darley-Usmar, +7 authors Harry Ischiropoulos
• Free radical biology & medicine
• 2012

The purpose of this position paper is to present a critical analysis of the challenges and limitations of the most widely used fluorescent probes for detecting and measuring reactive oxygen and… (More)

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.

• Robert J Lee, Guoxiang Xiong, +14 authors Noam A Cohen
• The Journal of clinical investigation
• 2012

Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of… (More)

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