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AIMS To study the distribution of clinically important red cell antibodies in pregnancy, and the associated fetal and neonatal morbidity and mortality. METHODS The case notes of women with clinically important red cell antibodies identified in their serum during pregnancy were reviewed. RESULTS During a 12 month period 22,264 women were referred for(More)
Piracetam, a derivative of γ-aminobutyric acid, exerts memory-enhancing and mild anxiolytic effects in human and rodent studies. To examine the drug's behavioral profile further, we assessed its effects on behavioral and endocrine (cortisol) responses of adult zebrafish (Danio rerio)--a novel model species rapidly gaining popularity in neurobehavioral(More)
In this paper I propose a novel treatment of generic sentences, which proceeds by means of different levels of analysis. According to this account, all generic sentences (I-generics and D-generics alike) are initially treated in a uniform manner, as involving higher-order predication (following the work of George Boolos, James Higginbotham and Barry Schein(More)
The metabolism and excretion of ziprasidone (5-[2-{4-(1,2benzisothiazol-3-yl)piperazin-1-yl}ethyl]-6-chloroindolin-2-one hydrochloride hydrate) were studied in Long Evans rats after oral administration of a single dose of a mixture of Cand H-labeled ziprasidone. The radioactive dose was quantitatively recovered over 7 days in both male and female rats. The(More)
OBJECTIVE To ascertain whether anti-D immunoglobulin is being administered to Rhesus D negative women in accordance with the 1991 recommendations for its use to cover all events which may result in fetomaternal haemorrhage. DESIGN The notes of women delivered in 1994 were examined for compliance with the 1991 recommendations. SETTING Seven maternity(More)
The discovery of two histamine H(3) antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in identifying these clinical candidates was the development of a compound design strategy that leveraged(More)
What is the difference between description and explanation in linguistics? We take explanation to be the reduction of description to independently motivated general principles. For language, a promising source of independently motivated general principles can be found in neuroscience, and especially computational neuroscience. As an example, we consider the(More)
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