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Amyloid beta (Abeta) immunoreactivity in neurons was examined in brains of 32 control subjects, 31 people with Down syndrome, and 36 patients with sporadic Alzheimer's disease to determine if intraneuronal Abeta immunoreactivity is an early manifestation of Alzheimer-type pathology leading to fibrillar plaque formation and/or neurofibrillary degeneration.(More)
Amyloid (A) immunoreactivity in neu-rons was examined in brains of 32 control subjects, 31 people with Down syndrome, and 36 patients with sporadic Alzheimer's disease to determine if intraneuronal A immunoreactivity is an early manifestation of Alz-heimer-type pathology leading to Wbrillar plaque formation and/or neuroWbrillary degeneration. The appearance(More)
The capillary network of the human cerebral cortex was morphometrically investigated in a young, aged and aged hypertonic group. In the aging cortex, augmented values of capillary diameter and volume are accompanied by smaller distances between capillaries and an extended length per unit cortex volume. An increased capillary diameter of the aged hypertonic(More)
The form and size of neurons in the cat cerebral cortex were stereologically investigated intravitally, and 30 sec., 5 hours, and 22 hours postmortem. For comparison, the human cerebral cortex of a 60 year old male subject was deep frozen 16 hours postmortem, and fixed in formalin. The stereologic parameters of the cat experiment included neuronal surface(More)