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Rotavirus outer-layer protein VP7 is a principal target of protective antibodies. Removal of free calcium ions (Ca2+) dissociates VP7 trimers into monomers, releasing VP7 from the virion, and… (More)
- Eric J. Kunkel, James J Campbell, +13 authors William W. Agace
- The Journal of experimental medicine
- 2000
The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial… (More)
- Donald N. Cook, Dina M. Prosser, +13 authors Sergio A Lira
- Immunity
- 2000
Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor… (More)
- Harry B Greenberg, Mary K. Estes
- Gastroenterology
- 2009
Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of… (More)
- Xiaosong He, Tyson H. Holmes, +6 authors Ann Margaret Arvin
- Journal of virology
- 2006
The patterns of cellular immune responses induced by live attenuated influenza vaccine (LAIV) versus those of the trivalent inactivated influenza vaccine (TIV) have not been studied extensively,… (More)
- Thomas Lorchan Lewis, Harry B Greenberg, John E Herrmann, Lister Staveley – Smith, Suzanne M Matsui
- Journal of virology
- 1994
We report the results from sequence analysis and expression studies of the gastroenteritis agent astrovirus serotype 1. We have cloned and sequenced 5,944 nucleotides (nt) of the estimated 7.2-kb RNA… (More)
- Sharon C. A. Chen, David A Jones, +4 authors John E Herrmann
- Journal of virology
- 1998
DNA vaccines are usually given by intramuscular injection or by gene gun delivery of DNA-coated particles into the epidermis. Induction of mucosal immunity by targeting DNA vaccines to mucosal… (More)
- Philip Ralph Dormitzer, Harry B Greenberg, Stephen C Harrison
- Journal of virology
- 2001
Rotavirus particles are activated for cell entry by trypsin cleavage of the outer capsid spike protein, VP4, into a hemagglutinin, VP8*, and a membrane penetration protein, VP5*. We have purified… (More)
- Adrish Sen, Andrea J P Pruijssers, Terence S Dermody, Adolfo GarcÃa-Sastre, Harry B Greenberg
- Journal of virology
- 2011
In mouse embryonic fibroblasts (MEFs), the bovine rotavirus (UK strain) but not the simian rhesus rotavirus (RRV) robustly triggers beta interferon (IFN-β) secretion, resulting in an IFN-dependent… (More)
- Franco Maria Ruggeri, Harry B Greenberg
- Journal of virology
- 1991
Two distinct patterns of neutralization were identified by comparing the neutralization curves of monoclonal antibodies (MAbs) directed at the two surface proteins, VP4 and VP7, of rhesus rotavirus.… (More)