Harry A. Phillips

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For the economical production of monoclonal antibodies (MAbs), the cell-culture medium must be optimized for three different phases: growth of the hybridomas, MAb productivity of the hybridomas, and MAb purification or downstream processing. Medium improvements are necessary to meet these requirements for large-scale MAb production. Information bearing on(More)
DURING the past decade a great deal of attention has been devoted to the development and application of one or more vectorcardiographic lead systems possessing certain highly desirable physical characteristics. The overriding design consideration has been that the lead system provide a truly Cartesian frame of reference for the display of cardiac vectors.(More)
A trickle-bed system employing inert matrices of vermiculite or polyurethane foam packed in the downcomer section of a split-flow air-lift reactor has been developed for hybridoma culture to enhance antibody productivity. This quiescent condition favoured occlusion and allowed the cells to achieve densities twelve fold greater (12.8 x 10(6) cells/ml reactor(More)
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