Harrison Nguyen

Learn More
IMPORTANCE Approximately 10% to 25% of patients treated with BRAF inhibitors develop cutaneous squamous cell carcinoma (SCC), but the mechanism responsible has not yet been determined. We report what we believe to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomavirus subtype 17 (HPV-17) were associated with cutaneous SCC that(More)
Game theory has long been used to model cognitive decision making in societies. While traditional game theoretic modelling has focused on well-mixed populations, recent research has suggested that the topological structure of social networks play an important part in the dynamic behaviour of social systems. Any agent or person playing a game employs a(More)
A 57-year-old white man with no significant past medical history presented to the county hospital emergency room with complaints of increasing fatigue and lightheadedness over the past year. Upon further questioning, he revealed a large ulcerative lesion on his upper back that he reported started as a small ulcer and progressed to its current size over a(More)
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer associated with the Merkel cell polyomavirus (MCPyV). The MCPyV genome, which is clonally integrated in the majority of MCCs, encodes the regulatory small T (sT) antigen. Previously, reports have established MCPyV sT antigen as a potent oncogene capable of inducing cell(More)
Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of(More)
UNLABELLED Fracture properties of composite-dentin beams bonded with a self-etching adhesive were tested following short term pretreatments to simulate potential degradation mechanisms (thermal cycling, immersion in 5% NaOCl, or fatigue cycling). Beams of rectangular cross-section were shaped to a size of approximately 0.87 x 0.87 x 10 mm and placed in a(More)
The human body offers a template for many state-of-the-art prosthetic devices and sensors. In this work, we present a novel, sensorized synthetic skin that mimics the natural multi-layered nature of mechanoreceptors found in healthy glabrous skin to provide tactile information. The multi-layered sensor is made up of flexible piezoresistive textiles that act(More)
PURPOSE BRAF-inhibition (BRAFi) therapy for advanced melanoma carries a high rate of secondary cutaneous squamous cell carcinoma (cSCC) and risk of other cancers. UV radiation and α-genus human papillomavirus (HPV) are highly associated with SCC, but a novel role for β-genus HPV is suspected in BRAFi-cSCC. Cutaneous β-HPV may act in concert with host and(More)
Purpose: BRAF-inhibition (BRAFi) therapy for advanced mel-anoma carries a high rate of secondary cutaneous squamous cell carcinoma (cSCC) and risk of other cancers. UV radiation and a-genus human papillomavirus (HPV) are highly associated with SCC, but a novel role for b-genus HPV is suspected in BRAFi-cSCC. Cutaneous b-HPV may act in concert with host and(More)
Derived from green tea leaves, sinecatechins (Veregen ®) ointment, 15% is a topical therapy that is FDA-approved to treat human papillomavirus (HPV)-induced external genital and perianal warts (EGW) in immunocompetent patients aged 18 years and older. In two phase 3 trials enrolling over 1,000 participants with EGW, a 16-week treatment regimen with(More)
  • 1