Harriet M. Joy

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PURPOSE To estimate the levels of basal ganglia iron levels in Parkinson's disease (PD) using the PRIME MR sequence at 3.0 Tesla, in relation to patients' motor symptom severity. MATERIALS AND METHODS Seventy patients with PD and 10 healthy controls underwent assessment of movement and MR imaging. Mean R2' relaxation rates were recorded in the substantia(More)
We present a case of trans-sphenoidal encephalomeningocele in association with a posterior cranial fossa malformation which fulfils the criteria for the Dandy-Walker complex [1]. Congenital cardiovascular defects were also present. An abnormality of neural crest development may be responsible for the combined occurrence of these anomalies.
Genitourinary complications are relatively common in inflammatory bowel disease, with a reported incidence of 4–23%, although they more frequently occur in established disease. We present the case of a 12-year-old boy, already under investigation for short stature, who only developed florid symptoms of colitis after removal of a large staghorn calculus. In(More)
A 16-month-old boy presented with isolated unilateral mydriasis. Fourteen months after initial presentation, he developed an acute oculomotor nerve palsy. His initial computed tomography scan, with contrast, was normal. Subsequent magnetic resonance imaging revealed an enlarging arachnoid cyst at the exit of the oculomotor nerve from the midbrain. Isolated(More)
Diabetes insipidus (DI) is rare in childhood and has a wide-ranging aetiology including the involvement of uncontrolled proliferation of dendritic cells in the hypothalamic-pituitary axis, characteristic of Langerhans cell histiocytosis (LCH). DI may manifest as a sequela of multisystem LCH disease involving skin, bone, liver, spleen and lymph nodes. In(More)
Focal calvarial lesions may present as a visible, palpable, or symptomatic lump; however, with increasing use of cross-sectional imaging they are often encountered as an incidental finding. Knowledge of the possible disease entities along with a structured approach to imaging is required to suggest an appropriate diagnosis and assist in management planning.(More)