Harpreet Sandhu

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Targeting the Ras/Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway represents a promising anticancer strategy. Recently, we have reported a novel class of potent and selective non-ATP-competitive MEK1/2 inhibitors with a unique structure and mechanism of action. RO5068760 is a representative of this class(More)
In this paper we had used modified Ad-hoc On Demand routing protocol(AODV) called AODV + to integrate MANET with Internet using a stationary gateway. The communication between the mobile nodes in MANET and fixed node in internet pass through the gateways. Gateway bridge up MANET and Internets. Due to the dynamic nature of MANET, the changes in topology are(More)
To present a novel approach of greatly enhancing aqueous solubility of a model weakly basic drug, haloperidol, by using weak acids that would not form salts with the drug and to attain physically stable form of amorphous drug by drying such aqueous solutions. Aqueous solubility of haloperidol in presence of increasing concentrations of four different weak(More)
The purpose of this study was to develop an amorphous solid dispersion (SD) of an extremely water-insoluble and very weakly basic drug, itraconazole (ITZ), by interaction with weak organic acids and then drying that would enhance dissolution rate of drug and physical stability of formulation. Aqueous solubility of ITZ in concentrated solutions of weak(More)
There are few reports and observational data that support the safety and efficacy of real-time ultrasound guided (USG) percutaneous dilatational tracheostomy (PDT) when compared with unguided tracheostomy. We performed real-time USG PDT in our intensive care unit (ICU) patients with the aim of providing safe and cost effective point-of-care management.(More)
In this paper, we study the problem of anonymizing high dimensional location-based RFID data for mining or research purposes. We consider the case where RFID cards are used for purchasing in place of magnetic cards. Databases containing such transactions of card holders could be very huge in number of records (equals to number of users) and dimensions(More)
BACKGROUND Pathogen inactivation (PI) is a new approach to blood safety that may introduce additional costs. This study identifies costs that could be eliminated, thereby mitigating the financial impact. STUDY DESIGN AND METHODS Cost information was obtained from five institutions on tests and procedures (e.g., irradiation) currently performed, that could(More)
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