Harold Skalka

Learn More
Patients with various macular and optic nerve abnormalities underwent Snellen acuity, transient VER acuity, and Arden grating testing. Snellen acuity was the coarsest of the 3 evaluations, generally falling after Arden scores and VER acuity had already undergone significant degradation. The Arden gratings appeared to be the most sensitive of the 3 tests,(More)
Lenticular reduced glutathione, diminished in all forms fo human cataract, requires flavin adenine dinucleotide as a coenzyme for glutathione reductase. Deficiency of riboflavin, a precursor of flavin adenine dinucleotide, has been believed by some to be associated with cataract formation. We evaluated the riboflavin nutritional status of healthy young(More)
For fear of endophthalmitis and siderosis, ferrous intraocular foreign bodies are usually removed as soon as they are discovered; markedly reduced, siderotic ERG changes are considered permanent. We report a patient who presented with a chronically retained intravitreal foreign body and significant clinical as well as electrophysiologic signs of siderosis.(More)
Red cells and the lens of the eye are non-nucleated cells; moreover, they have metabolic similarities. Cataracts develop in childhood in homozygotes for galactosaemic abnormalities, which can be detected by biochemical measurements in red blood-cells. It has not been determined whether heterozygotes for these defects are at greater risk for cataract(More)
One hundred forty-seven patients, 144 with advanced cataract formation, had determinations of erythrocyte galactokinase and galactose-1-phosphate uridyl transferase performed. Significant reduction (more than 2 SDs) of one of these enzymes was found in 47.4% of patients 50 years old or less with presenile "idiopathic" bilateral cataracts, 7.1% of other(More)
A family in which two male siblings were affected with Wiskott-Aldrich syndrome (WAS) was studied using G-6-PD isoenzymes as an X-linked marker in order to investigate the nature of cellular abnormalities. Isolated peripheral blood cell types from the doubly heterozygous mother of the affected males seemingly failed to express the G-6-PD allele in cis(More)
Gas-liquid chromatography was employed to determine free monosaccharides in human, rat, and South American rodent Octodon degu lenses. In addition to D-glucose, D-fructose, sorbitol and myo-inositol, which were previously known to be components of lens tissue, glycerol, erythritol, threitol, ribitol, xylitol, and mannitol were also detected in the lenses of(More)
A father and son with pigmented paravenous retinochoroidal atrophy demonstrated the classical fundus appearance of bilateral sharply circumscribed patches of retinochoroidal atrophy and pigmentation along the retinal veins. Our patients, and the preponderance of males in previously reported cases of this disease, suggest the possibility of Y-chromosome(More)