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In 1986, the National Library of Medicine (NLM) assembled a large multidisciplinary, multisite team to work on the Unified Medical Language System (UMLS), a collaborative research project aimed at reducing fundamental barriers to the application of computers to medicine. Beyond its tangible products, the UMLS Knowledge Sources, and its influence on the(More)
The National Library of Medicine is charged with the development and management of a National Biomedical Communications Network. The Regional Medical Library Program is a forerunner of such a network; the product and institutions involved will be critical elements in its evolution. The immediate objective of the RMLP, the facilitation of biomedical(More)
Medical informatics attempts to provide the theoretic and scientific basis for the use of automated information systems in biomedicine. Even though a new field, its roots are in the 19th century. The National Library of Medicine (NLM) began classifying the medical literature and publishing the Index Medicus in 1897; in the early 1960s, the growth of the(More)
Builders of expert systems have generally accepted the principle that computer software should not be subject to government regulation if health care practitioners can be expected to interpret and apply the systems intelligently. The purpose of this paper is to identify the information that builders must make available to permit health care practitioners to(More)
The evolution of today's information age is mirrored in the growth of the National Library of Medicine's bibliographic services: from the pioneering work of the Library in the last century to develop Index Medicus, to developing the innovative computerized MEDLARS system in the early 1960s, to the easily searchable on-line data bases now available to health(More)
The rapid advances in computer and communication technology in the 1970's have enabled large interactive scientific and technical information retrieval systems to be implemented. Major search services today offer on-line access to millions of bibliographic citations and an increasing number of "electronic handbooks." In addition, development of knowledge(More)
While studying the agglutinating and precipi tating properties of guinea pig serum for leukemic cells and tissues (4, 5), we became interested in central nervous system tissue because it gave a precipitin reaction with guinea pig serum. In a series of preliminary experiments undertaken to determine the transmissibility of AKR lymphoma into young adult AKR(More)