Harold L. Andrews

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Legionella pneumophila, the causative agent of Legionnaires' pneumonia, replicates within alveolar macrophages by preventing phagosome-lysosome fusion. Here, a large number of mutants called dot (defective for organelle trafficking) that were unable to replicate intracellularly because of an inability of the bacteria to alter the endocytic pathway of(More)
Legionella pneumophila replicates within a specialized phagosome in cultured cells, a function necessary for its pathogenicity. The replicative phagosome lacks membrane marker proteins, such as the glycoprotein LAMP-1, that are indicators of the normal endocytic pathway. We describe the isolation of several Legionella genes essential for intracellular(More)
Machines that match the communication skills of Hal, the computer from 2001, are still remote, but viable and cost-effective speech products can be realized. H omer Dudley's Voder reported-Hly created quite a stir at the 1939 World's Fair in New York. This voice operation demonstrator, a box somewhat like an old-fashioned organ with a small keyboard and(More)
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