Harold J. Wanebo

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Trichostatin A (TSA), a hydroxamate-type inhibitor of mammalian histone deacetylases, is emerging as one of a potentially new class of anticancer agents. TSA is known to act by promoting the acetylation of histones, leading to uncoiling of chromatin and activation of a variety of genes implicated in the regulation of cell survival, proliferation,(More)
OBJECTIVE To determine the effect of several wound factors on melanoma growth in a mouse model. DESIGN Cohort analytic study. SETTING Animal research facility of Roger Williams Medical Center, Providence, RI. STUDY GROUP Seventeen groups of 5 C57BL/6 mice each. INTERVENTIONS A surgical wound was created in 1 hind limb, after which different(More)
An overview of colorectal cancer discussed (Philip Paty) the good outcome after primary management with local control in 90–95 % of colon and 85 % in rectal cancer patients with major progression to metastases and to death related to hematogenous dissemination. The major disease pathways include the APC, aneuploid pathway involving mutations of P53, KRAS,(More)
OBJECTIVE To determine the impact of sentinel lymph node (SLN) status and other risk factors on recurrence and overall survival in head and neck melanoma patients. DESIGN The SLN Working Group, based in San Francisco, Calif, with its 11 member centers, the John Wayne Cancer Institute, and The University of Texas M. D. Anderson Cancer Center pooled data on(More)
Purpose: We sought to evaluate the correlation between tissue biomarker expression (using standardized , quantitative immunofluorescence) and clinical outcome in the E2303 trial. Experimental Design: Sixty-three eligible patients with operable stage III/IV head and neck squamous cell cancer (HNSCC) participated in the Eastern Cooperative Oncology Group(More)
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. The objective of the present study is to evaluate correlation between tissue biomarker expression (measured by automated quantitative protein analysis, AQUA) and clinical outcome in E2303, a phase II trial of induction chemotherapy with weekly cetuximab,(More)
Exogenous cell-permeable C6 ceramide has been demonstrated to act synergistically with chemotherapeutic drugs, including paclitaxel, cisplatin, doxorubicin and the histone deacetylase inhibitor, trichostatin A, to induce cell death in a variety of cancer cells. We previously demonstrated that C6 ceramide and paclitaxel function synergistically to induce(More)
The present issue of the International Journal of Surgical Oncology on Pelvic Surgery contains a series of articles on prostate cancer, gynecologic malignancies, and rectal cancer. The article on " radical prostatectomy as a first-line treatment in patients with initial PSA >20 ng/mL " by Hinev et al. reports on patients diagnosed with prostate cancer (PCa)(More)
Previous reports have shown that breast cancer patients have exhibited leukocyte migration inhibition test (LMIT) responses to antigenic preparations of the MCF-7 breast cancer cell line, murine mammary tumor virus (MTV), and the T-antigen (Thom sen-Friedenreich antigen), a precursor of the M and N blood group system. We have previously demonstrated(More)
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