Harold Hutchinson

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We studied the clinical spectrum associated with secondary plasma carnitine deficiency in 51 pediatric patients. Forty-three patients had total plasma carnitine values below 20 mumol/L and an additional eight patients had total values above 20 mumol/L but had low free plasma carnitine levels. The clinical presentation in the patients with total plasma(More)
UNLABELLED Heart failure is associated with a decreased variability in circadian systolic blood pressure. ACE inhibitors have been shown to be beneficial in CHF. However, the effect of the magnitude of the dose of ACE inhibitor on blood pressure variability has not been reported. The objective of this sub-study of the ATLAS trial was to determine if there(More)
Magnetic resonance imaging (MRI) offers a sensitive alternative to computed tomography (CT) for lesion localization. Patients with subacute necrotizing encephalomyelopathy (SNE) may be diagnosed by finding focal lesions on CT that correspond to sites of anatomical involvement. We report serial CT and MRI scanning findings in a patient with clinical,(More)
The content and fatty acyl composition of phospholipids were examined in pressure-overload hypertrophied hearts. Cardiac hypertrophy was induced in rats by abdominal aortic constriction. Twenty-one days postconstriction the content of myocardial phosphatidylcholine (PC), sphingomyelin, and phosphatidylinositol (PI) was significantly elevated by 10, 10, and(More)
A patient is described in whom intravenous magnesium sulfate, administered for preeclampsia, successfully treated hypercalcemia associated with hyperparathyroidism. This single case suggests that magnesium sulfate might be an effective alternative to standard medical or surgical treatment of this condition.
We argue that the Soros account of reflexivity does not provide a clear-cut distinction between a social science such as economics and the physical sciences. It is pointed out that the participants who attempt to learn from refutations of conjectures in the Soros world are likely to be haunted by the Duhem-Quine problem of conjointness of hypotheses and(More)