Harold Dickensheets

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2595 IL-4 and-13 are related cytokines, encoded by closely linked genes (1). IL-4 can signal through either the type I (IL-4R ␣ / ␥ c) or the type II (IL-4R ␣ /-13R ␣ 1) IL-4 receptor, whereas IL-13 signals exclusively via the type II IL-4 receptor (2). IL-4 binds to IL-4R ␣ with high affi nity, triggering receptor heterodimerization either with ␥ c or with(More)
TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We found that LPS treatment activated ISGF3 and(More)
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