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Previous studies have shown that a single dose of methylnaltrexone, a unique peripheral opioid antagonist, reverses opioid-induced gut hypomotility in humans. Because repeated drug doses are likely… Continue Reading
L'invention concerne la synthese stereoselective de (R)-N-methylnaltrexone (R-MNTX) et de ses intermediaires, des preparations pharmaceutiques comprenant R-MNTX ou ses intermediaires et des methodes… Continue Reading
A compound of the formula: ** ** Formula wherein R is isobutyryl and X- is a counterion, wherein the compound is in the (R) configuration with respect to nitrogen.