Harold Brunn

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Exact quantitative determinations of either digitalis or its derivatives in the blood of patients or animals receiving these drugs have never been accomplished. The prime difficulty of course has been the inability to detect relatively minute amounts of digitalis or allied cardiotonic drugs in body fluids. Because of the absence of such quantitative data,(More)
The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet. Injections of gabexate and proglumide from(More)
T lIE D)IGITALIS glycosides have proved themselves so efficacious imi the treatment of various cardiac disorders that it is ire(uenitly forgotten that, nievertheless, there is little exact knowledge ahout either the pharmacologic or physiologic properties of these substances. For example, the exact quantitative aspects of the processes by which digitalis(More)
  • Harold Brunn
  • Food and chemical toxicology : an international…
  • 1984
Laying hens were given a single oral dose of 2,2',4,5'-tetrachloro[14C]biphenyl ([14C]TCB). Within 11 days of administration, 54.8% of the original dose was excreted in the faeces. Examination of eggs laid within this period showed that 11.7% of the original dose was present in the yolks. The biological half-life of [14C]TCB in hens was 7 days. In hens(More)
Recently we have described (1) the sequence of phenomena that followed the experimental placement of a thrombus in the aorta of a hypercholesterolemic rabbit. It was found that the thrombus invariably elicited a hyperplastic intimal response leading eventually to a plaque (see Color Figure 1) which in its lipid and tissue characteristics bore a striking(More)
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