Harold B. Brooks

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The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes to the proliferation of a subset of lung cancer cell lines by supporting oncogenic RAS transcriptional responses. NSD2 knock down combined with MEK or(More)
Although only 6% of the estimated 518 protein kinases [1] encoded in the human genome have had structures of their catalytic domains determined by X-ray crystallography, structure-based design techniques can significantly aid in the discovery of novel kinase inhibitors across this protein class. Conservation of the ATP binding site between known kinase(More)
The standard cell plays a very important role in the maintenance of the electrical units and in correlating the units of the various national laboratories. Modern standard cells have attained such a high degree of reproducibility and permanence as to warrant the use of apparatus of the utmost precision and reliability in their intercomparison. The paper(More)
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