Harold A Silverman

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Inflammatory conditions characterized by excessive peripheral immune responses are associated with diverse alterations in brain function, and brain-derived neural pathways regulate peripheral inflammation. Important aspects of this bidirectional peripheral immune-brain communication, including the impact of peripheral inflammation on brain region-specific(More)
Phenytoin is known to reduce neural overactivity (pseudomyotonia) affecting the hind limb musculature in C57B1/6J dystrophic (dy2J/dy2J) mice. This study reports a change in the metabolic profile of superficial gastrocnemius muscle fibers from dy2J/dy2J animals after chronic phenytoin treatment. The superficial gastrocnemius muscle region from normal mice(More)
The gills of freshwater mussels perform many functions that depend on water flow through the water canals and channels. Regulation of water flow depends in part on ciliary activity and in part on the contraction of musculature underlying the gill filament and water channel epithelium. Obliquely striated muscles control water canal openings (ostia) at the(More)
The hind limb muscles of dy2J/dy2J mice appear more oxidative than normal hind limb muscles when assayed histochemically. In some cases, biochemical assay of oxidative capacity does not match histochemical data, and in some dy2J mice, particularly old animals, there appears to be a decline in biochemically assayed oxidative enzymes. The current study(More)
Adult pigeons received dantrolene sodium, a skeletal muscle relaxant which blocks the release of calcium during excitation-contraction coupling, for 12 to 16 weeks. The pectoralis muscles of these birds were analyzed for changes occurring in the various fiber types of the muscle. Both histochemistry (ATPase and SDH activity) and electron microscopy(More)
The book begins with an excellent section on the methodology for starting and maintaining cell and organ cultures from human biopsy specimens. Techniques for growing monolayer cultures, cell suspension cultures, free-floating slice cultures, and organ cultures of several types are presented clearly and in detail. Subsequent sections ofthe book describe the(More)
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