Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse
- A. Carey, Elizabeth I Sypek, Harminder Singh, M. Kaufman, J. McLaughlin
- Biology, PsychologyBehavioural Brain Research
- 1 April 2012
Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice
- D. Verma, B. Moghimi, H. Daniell
- Biology, MedicineProceedings of the National Academy of Sciences
- 29 March 2010
This prophylactic protocol using a murine hemophilia B model was effective over a range of oral antigen doses, and controlled inhibitor formation and anaphylaxis long-term, up to 7 months (∼40% life span of this mouse strain).
Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat
- J. Paris, Harminder Singh, M. Ganno, P. Jackson, J. McLaughlin
- Biology, PsychologyPsychopharmacology
- 1 June 2014
Among GT-tg mice, doxycycline significantly increased anxiety-like behavior in all tasks, commensurate with enhanced Western blot labeling of Tat1-86 protein in brain, displaying optimal effects with the 7-day regimen.
Physical Presence of Nor-Binaltorphimine in Mouse Brain over 21 Days after a Single Administration Corresponds to Its Long-Lasting Antagonistic Effect on κ-Opioid Receptors
- Kshitij A. Patkar, Jinhua Wu, J. McLaughlin
- BiologyJournal of Pharmacology and Experimental…
- 1 September 2013
Overall, the physical presence of nor-BNI in the mouse brain paralleled its in vivo pharmacological profile, suggesting physicochemical and pharmacokinetic properties of nor -BNI may contribute to the prolonged KOR antagonism.
Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.
Inhibition of Golgi alpha-mannosidase II (GMII), which acts late in the N-glycan processing pathway, provides a route to blocking cancer-induced changes in cell surface oligosaccharide structures. To…
Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice
- J. Paris, Harminder Singh, A. Carey, J. McLaughlin
- Biology, PsychologyBehavioural Brain Research
- 15 September 2015
Wax Ester Synthesis is Required for Mycobacterium tuberculosis to Enter In Vitro Dormancy
- T. Sirakova, C. Deb, P. Kolattukudy
- BiologyPLoS ONE
- 14 December 2012
The results indicate that the fcr1 and fcr2 gene products are involved in THE AUTHORS synthesis under in vitro dormancy-inducing conditions and that THEY play a critical role in reaching a dormant state in mycobacterial dormancy.
Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat
- J. Paris, Harminder Singh, M. Ganno, P. Jackson, J. McLaughlin
- Biology, PsychologyPsychopharmacology
- 19 December 2013
Among GT-tg mice, doxycycline significantly increased anxiety-like behavior in all tasks, commensurate with enhanced Western blot labeling of Tat1-86 protein in brain, displaying optimal effects with the 7-day regimen.
Visualization of third-level information in latent fingerprints by a new fluorogenic L-tyrosine analogue.
- Harminder Singh, S. Verma
- BiologyChemical Communications
- 4 May 2021
The design of two stable, fluorescent l-tyrosine analogs, FHBY and BHBY, exhibiting photophysical properties associated with the AIE-coupled ESIPT mechanism, are described, for fluorescent reporting of latent fingerprints.
Purification and Characterization of Novel Toxin Produced by Vibrio cholerae O1
- K. Walia, Sujata Ghosh, Nirmalya Ganguly
- BiologyInfection and Immunity
- 1 October 1999
It is indicated that WO7 toxin is structurally and functionally distinct from other cholera toxins and that the enterotoxic activities expressed by WO6 toxin appear to contribute to the pathogenesis of disease associated with V. cholerae O1 strains.
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