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Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice
This prophylactic protocol using a murine hemophilia B model was effective over a range of oral antigen doses, and controlled inhibitor formation and anaphylaxis long-term, up to 7 months (∼40% life span of this mouse strain).
Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse
Evidence is provided that Tat protein expression is sufficient to mediate cognitive abnormalities seen in HIV-infected individuals and the genetically engineered GT-tg mouse may be useful for improving the understanding of the neurological underpinnings of neuroAIDS-related behaviors.
Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat
Among GT-tg mice, doxycycline significantly increased anxiety-like behavior in all tasks, commensurate with enhanced Western blot labeling of Tat1-86 protein in brain, displaying optimal effects with the 7-day regimen.
Physical Presence of Nor-Binaltorphimine in Mouse Brain over 21 Days after a Single Administration Corresponds to Its Long-Lasting Antagonistic Effect on κ-Opioid Receptors
Overall, the physical presence of nor-BNI in the mouse brain paralleled its in vivo pharmacological profile, suggesting physicochemical and pharmacokinetic properties of nor -BNI may contribute to the prolonged KOR antagonism.
Wax Ester Synthesis is Required for Mycobacterium tuberculosis to Enter In Vitro Dormancy
The results indicate that the fcr1 and fcr2 gene products are involved in THE AUTHORS synthesis under in vitro dormancy-inducing conditions and that THEY play a critical role in reaching a dormant state in mycobacterial dormancy.
Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.
Inhibition of Golgi alpha-mannosidase II (GMII), which acts late in the N-glycan processing pathway, provides a route to blocking cancer-induced changes in cell surface oligosaccharide structures. To
Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice
Exposure to HIV-1 Tat protein induced sensorimotor deficits associated with acute and persistent neuroinflammation in limbic/extralimbic brain regions and increased frontal cortex GFAP.
Purification and Characterization of Novel Toxin Produced by Vibrio cholerae O1
It is indicated that WO7 toxin is structurally and functionally distinct from other cholera toxins and that the enterotoxic activities expressed by WO6 toxin appear to contribute to the pathogenesis of disease associated with V. cholerae O1 strains.