Harm Peters

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Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and pharmacokinetics of single-dose infusions of fresolimumab, a human monoclonal antibody that inactivates all forms of transforming growth factor-β (TGF-β), in a phase I open-label, dose-ranging study. Patients(More)
INTRODUCTION Mechanical ventilation (MV) is a life saving intervention in acute respiratory failure without alternative. However, particularly in pre-injured lungs, even protective ventilation strategies may evoke ventilator-induced lung injury (VILI), which is characterized by pulmonary inflammation and vascular leakage. Adjuvant pharmacologic strategies(More)
—The gap between application specific integrated circuits (ASICs) and general-purpose programmable processors in terms of performance, power, cost and flexibility is well known. Application specific instruction-set processors (ASIPs) bridge this gap. In this work, we demonstrate the key benefits of ASIPs for several video applications. One of the most(More)
Video encoders are an important IP block in mobile multimedia systems. In this paper, we describe a low-cost low-power multi-standard (MPEG4, JPEG, and H.263) video/image encoder. The low-cost and low-power aspects are achieved by the right choice of algorithms and architectures. In the algorithm front, an embedded compression technique for reducing the(More)
To address the high data bus bandwidth requirements, the principle of locality of reference is exploited in the vast majority of video processing algorithms. Especially, for appli-cation's kernels based on motion estimation, it is inevitable to fetch the pixel data from a local storage. However, the video application kernel requirements can vary(More)
INTRODUCTION Regional citrate anticoagulation (RCA) for continuous renal replacement therapy is widely used in intensive care units (ICUs). However, concern exists about the safety of citrate in patients with liver failure (LF). The aim of this study was to evaluate safety and efficacy of RCA in ICU patients with varying degrees of impaired liver function.(More)
AIM The Berlin project "Interprofessional teaching and learning in medicine, occupational therapy, physiotherapy and nursing" (INTER-M-E-P-P) pursues the goal of developing and testing interprofessional courses in an exemplary manner, and then implement these into their regular study programs. METHOD Under the direction of a steering committee of the(More)
BACKGROUND Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly(More)
BACKGROUND Interleukin-17 (IL-17) is a new pro-inflammatory cytokine involved in immune response and inflammatory disease. The main source of IL-17 is a subset of CD4+ T-helper cells, but is also secreted by non-immune cells. The present study analyzes expression of IL-17 in the time course of acute anti-thy1 glomerulonephritis and the role of IL-17 as a(More)