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To address the high data bus bandwidth requirements, the principle of locality of reference is exploited in the vast majority of video processing algorithms. Especially, for appli-cation's kernels based on motion estimation, it is inevitable to fetch the pixel data from a local storage. However, the video application kernel requirements can vary(More)
Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and pharmacokinetics of single-dose infusions of fresolimumab, a human monoclonal antibody that inactivates all forms of transforming growth factor-β (TGF-β), in a phase I open-label, dose-ranging study. Patients(More)
— The gap between application-specific integrated circuits (ASICs) and general-purpose programmable processors in terms of performance, power, cost and flexibility is well known. Application-specific instruction-set processors (ASIPs) bridge this gap. In this work, we demonstrate the key benefits of ASIPs for several video applications. One of the(More)
INTRODUCTION Mechanical ventilation (MV) is a life saving intervention in acute respiratory failure without alternative. However, particularly in pre-injured lungs, even protective ventilation strategies may evoke ventilator-induced lung injury (VILI), which is characterized by pulmonary inflammation and vascular leakage. Adjuvant pharmacologic strategies(More)
Video encoders are an important IP block in mobile multimedia systems. In this paper, we describe a low-cost low-power multi-standard (MPEG4, JPEG, and H.263) video/image encoder. The low-cost and low-power aspects are achieved by the right choice of algorithms and architectures. In the algorithm front, an embedded compression technique for reducing the(More)
INTRODUCTION Regional citrate anticoagulation (RCA) for continuous renal replacement therapy is widely used in intensive care units (ICUs). However, concern exists about the safety of citrate in patients with liver failure (LF). The aim of this study was to evaluate safety and efficacy of RCA in ICU patients with varying degrees of impaired liver function.(More)
BACKGROUND Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly(More)
Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully treated with NPV alone. This patient and(More)
Multiple myeloma (MM) is a malignancy with excessive production of monoclonal proteins. At disease presentation 30% of MM patients have significant renal impairment which may progress to renal failure requiring dialysis. Besides chemotherapy extracorporeal elimination procedures such as plasma exchange have been applied as adjuvant strategies to eliminate(More)