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BACKGROUND Surgery for spinal stenosis is widely performed, but its effectiveness as compared with nonsurgical treatment has not been shown in controlled trials. METHODS Surgical candidates with a history of at least 12 weeks of symptoms and spinal stenosis without spondylolisthesis (as confirmed on imaging) were enrolled in either a randomized cohort or(More)
BACKGROUND Modern clinical-research practice favors placebo controls over usual-care controls whenever a credible placebo exists. An unrecognized consequence of this preference is that clinicians are more limited in their ability to provide the benefits of the non-specific healing effects of placebos in clinical practice. METHODS We examined the issues in(More)
BACKGROUND Previous meta-analyses described moderate to large benefits of chondroitin in patients with osteoarthritis. However, recent large-scale trials did not find evidence of an effect. PURPOSE To determine the effects of chondroitin on pain in patients with osteoarthritis. DATA SOURCES The authors searched the Cochrane Central Register of(More)
BACKGROUND Despite ethical imperatives, informing research participants about the results of the studies in which they take part is not often performed. This is due, in part, to the costs and burdens of communicating with each participant after publication of the results. METHODS Following the closeout and publication of a randomized clinical trial of saw(More)
Importance Oral steroids are commonly used to treat acute sciatica due to a herniated disk but have not been evaluated in an appropriately powered clinical trial. Objective To determine if oral prednisone is more effective than placebo in improving function and pain among patients with acute sciatica. conducted from 2008 to 2013 in a large integrated health(More)
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