Harish Kumar Tiwari

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BACKGROUND The anti-folate drug methotrexate (MTX) is commonly used to treat rheumatoid arthritis. OBJECTIVE To determine the allele frequencies of five common coding single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene in African-Americans and Caucasians with rheumatoid arthritis and controls to assess whether(More)
African-Americans have been under-represented in genetic studies of rheumatoid arthritis (RA) susceptibility and severity. Genetic and non-genetic factors influencing the radiographic severity of RA and its response to treatment are poorly understood, particularly in African-Americans. The Consortium for the Longitudinal Evaluation of African-Americans with(More)
This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for the prevention of mastitis using the mouse as a model system. Mice immunized with formalin-killed whole cell vaccine of S. aureus residing in a biofilm when delivered via an intramammary route produced a cell mediated(More)
Protein A, encoded by the spa gene, is one of the major immune evading MSCRAMM of S. aureus, demonstrated to be prevalent in a significant percentage of clinical bovine mastitis isolates in Australia. Given its' reported significance in biofilm formation and the superior performance of S. aureus biofilm versus planktonic vaccine in the mouse mastitis model,(More)
OBJECTIVE To assess if Staphylococcus aureus is transmitted between man and animals & vice-versa. METHODS Staphylococcus aureus belonging to biotype C (bovine origin) were isolated from nares and hands of workers on six dairy farms of Assam and Meghalaya. The cows on the farms had a high rate of prevalence of mastitis caused by the same biotype of S.(More)
The concentration of Terramycin and Furazolidone residues in broiler meat following their subtherapeutic use in the ration of the birds were detected as 296 ng/g, 174 ng/g, 40 ng/g, 60 ng/g and 124 ng/ml in kidney, liver, thigh muscle, breast muscle and serum for Terramycin and 270 ng/g 160 ng/g and 88 ng/ml in kidney, liver and serum for Furazolidone. One(More)
BACKGROUND Biofilm formation by Staphylococcus aureus is an important virulence attribute because of its potential to induce persistent antibiotic resistance, retard phagocytosis and either attenuate or promote inflammation, depending upon the disease syndrome, in vivo. This study was undertaken to evaluate the potential significance of strength of biofilm(More)
Mastitis is one of the most economically significant diseases for the dairy industry for backyard farmers in developing countries and high producing herds worldwide. Two of the major factors impeding reduction in the incidence of this disease is [a] the lack of availability of an effective vaccine capable of protecting against multiple etiological agents(More)
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