Harish Chander

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BACKGROUND We previously reported that the degradation of prohibitin by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53. We also reported that MMTV-Skp2B transgenic mice develop mammary gland tumors that are characterized by an increased proteolytic cleavage of the insulin-like growth factor binding protein 4 (IGFBP-4), an(More)
Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) in TNBC metastasis in vivo, and profile CIP4 expression in human breast cancer patients. In human TNBC cells, CIP4 knock-down (KD) led(More)
Aberrant epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer (NSCLC) is linked to tumor progression, metastasis and poor survival rates. Here we report the role of Cdc42-interacting protein 4 (CIP4) in the regulation of NSCLC cell invasiveness and tumor metastasis. CIP4 was highly expressed in a panel of NSCLC cell lines and(More)
Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in the tumor suppressor p53, we tested whether p53 regulates Toca-1 expression. Normal mammary epithelial cells (HBL-100, MCF10A) and breast cancer cell(More)
This paper is presented to review the human speech production mechanism with an intention to portray different aspects involved in it, right from generation of thought in the mind to the production of sound wave from mouth. Speech production in human beings is a very common phenomenon which is experienced in their day to day life and is also part of speech(More)
Track and field events place different demands on athletes and may have an effect on balance. This study investigated the effects of event specialty, gender, and leg dominance on balance among adolescent track and field athletes. Forty healthy adolescent track and field athletes (male = 23, female = 17) categorised into three different groups (sprinter =(More)
Slips occur as a result of failure of normal locomotion. The purpose of this study is to analyze the impact of alternative footwear [Crocs™ (CC), flip-flops (FF)] and an industry standard low top slip resistant shoe (SRS)] under multiple gait trials [normal dry (NG); unexpected slip (US), alert slip (AS) and expected slip (ES)] on lower extremity joint(More)
Purpose – The purpose of the study is to explore the publication trends of the scholarly journal Library Management, and highlight its various important aspects. Design/methodology/approach – The paper presents results of bibliometric analysis of 336 articles which were published during the period 2006-2012, in the Library Management journal of Emerald.(More)
We have recently reported that fibrillar amyloid beta-protein (Abeta) inhibits the proteolytic activity of trypsin and high molecular weight bovine brain protease. We report here that trypsin binds to fibrillar Abeta (fAbeta) and the resulting complex of trypsin/fAbeta is sodium dodecyl sulfate (SDS)-stable. Electron microscopic analysis confirmed the(More)
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