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EVOLUTION OF PERIODONTICS: AN INSIGHT INTO THE PAST
The specialty of Periodontics has a long history dating back to prehistoric written evidence. Ancient Indian and Chinese describe scurvy and advocate cleansing of teeth for health. On through the… Expand
Indirect enantioseparation of proteinogenic amino acids using naproxen-based chiral derivatizing reagent and HPLC.
Diastereomers of 18 proteinogenic amino acids were synthesized under microwave irradiation and by vortexing using (S)-naproxen-benzotriazole as chiral derivatizing reagent. The diastereomers… Expand
Indirect enantioseparation of selenomethionine by reversed-phase high-performance liquid chromatography using a newly synthesized chiral derivatizing reagent based on (S)-naproxen moiety.
(S)-Naproxen was reacted with N-hydroxyphthalimide in the presence of coupling reagent dicyclohexylcarbodiimide, and a new chiral derivatizing reagent, phthalimidyl-(S)-naproxen ester, was… Expand
Enantioseparation of Orciprenaline, Betaxolol, and Propranolol using HPLC and New Chiral Reagents Based on 1,5-Difluoro-2,4-dinitrobenzene
Diastereomers of three β-blockers (orciprenaline, betaxolol, and propranolol) were synthesized using three new chiral derivatizing reagents that were prepared by substituting one fluorine atom in… Expand
Resolution of enantiomers with both achiral phases in chromatography: conceptual challenge
A new practical approach has been adopted for the resolution (from racemic and non-racemic mixtures) of DL-selenomethionine using achiral phase chromatography supplemented with (−)-quinine as a… Expand
Enantioresolution of DL-selenomethionine by thin silica gel plates impregnated with (−) quinine and reversed-phase TLC and HPLC separation of diastereomers prepared with difluorodinitrobenzene based…
(−)-Quinine was used as a chiral selector by adopting three approaches in TLC for direct enantioresolution of DL-selenomethionine; these included impregnation of plate by chiral selector and its use… Expand
Resolution and isolation of enantiomers of (±)-isoxsuprine using thin silica gel layers impregnated with L-glutamic acid, comparison of separation of its diastereomers prepared with chiral…
Thin silica gel layers impregnated with optically pure l-glutamic acid were used for direct resolution of enantiomers of (±)-isoxsuprine in their native form. Three chiral derivatizing reagents,… Expand
Enantioresolution of Three Active Pharmaceutical Ingredients by Different Thin-Layer Chromatographic Approaches
- Hariom Nagar, J. Martens, R. Bhushan
- JPC – Journal of Planar Chromatography – Modern…
- 21 September 2017
Enantioresolution of three active pharmaceutical ingredients (APIs), namely, atenolol, betaxolol, and orciprenaline, marketed as racemic mixture, has been achieved in a direct mode using (S)-glutamic… Expand
Enantiomeric separation of fluoxetine on C18 column using DFDNB based chiral derivatizing reagent having L-amino acids as chiral auxiliaries
ENANTIOSEPARATION OF ORCIPRENALINE, USING HPLC AND CHIRAL REAGENT BASED ON DFDNB
Orciprenaline is a moderately selective β-adrenergic receptor agonist and used in the treatment of asthma. Generally, the (S)-( ̶ )-enantiomer of β-blockers is pharmacologically effective, show about… Expand