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Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin
Proper telomeric chromatin configuration is thought to be essential for telomere homeostasis and stability. Previous studies in mouse suggested that loss of heterochromatin marks at telomeres mightExpand
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TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1.
A significant fraction (∼10%) of cancer cells maintain their telomere length via a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). There are no known molecular,Expand
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Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated withExpand
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Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
The AMPK/PGC-1α metabolic pathway and nuclear respiratory factor 1 up-regulate human telomere transcription. DNA breaks activate the DNA damage response and, if left unrepaired, trigger cellularExpand
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Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells
ABSTRACT Mutations in ATRX (alpha thalassemia/mental retardation syndrome X-linked), a chromatin-remodeling protein, are associated with the telomerase-independent ALT (alternative lengthening ofExpand
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Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
PARN, poly(A)-specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated withExpand
Specific death of ALT cells through TSPYL5 depletion
ABSTRACT Some tumors acquire replicative immortality by activating an ALTernative telomerase-independent telomere maintenance mechanism. ALT offers interesting therapeutic perspectives but lacks anyExpand