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- Publications
- Influence
TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1.
- H. Episkopou, A. Diman, Eloïse Claude, N. Viceconte, A. Decottignies
- Biology, Medicine
- Molecular cell
- 8 August 2019
A significant fraction (∼10%) of cancer cells maintain their telomere length via a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). There are no known molecular,… Expand
Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
- M. Benyelles, H. Episkopou, +12 authors P. Revy
- Biology, Medicine
- EMBO molecular medicine
- 1 July 2019
PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated with… Expand
Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
- A. Diman, Joanna Boros, +7 authors A. Decottignies
- Biology, Medicine
- Science Advances
- 1 July 2016
The AMPK/PGC-1α metabolic pathway and nuclear respiratory factor 1 up-regulate human telomere transcription. DNA breaks activate the DNA damage response and, if left unrepaired, trigger cellular… Expand
Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells
- Rita Eid, M. Demattéi, +4 authors M. Charbonneau
- Biology, Medicine
- Molecular and Cellular Biology
- 8 June 2015
ABSTRACT Mutations in ATRX (alpha thalassemia/mental retardation syndrome X-linked), a chromatin-remodeling protein, are associated with the telomerase-independent ALT (alternative lengthening of… Expand
Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
- M. Benyelles, H. Episkopou, +12 authors P. Revy
- Medicine
- EMBO molecular medicine
- 6 June 2019
PARN, poly(A)-specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated with… Expand
Assessment of senescence in adipose mesenchymal stem cells for optimized ex vivo expansion and therapeutic potential
- H. Episkopou, D. Anabelle, N. Theys
- Biology
- 1 May 2020
Background & Aim Bone tissue engineering using osteoblastic differentiated adipose mesenchymal stem cells (AMSCs) is tested in clinical trials to heal critical size bone defects such as bone… Expand
Specific death of ALT cells through TSPYL5 depletion
- Eloïse Claude, H. Episkopou, A. Decottignies
- Biology, Medicine
- Molecular & cellular oncology
- 11 September 2019
ABSTRACT Some tumors acquire replicative immortality by activating an ALTernative telomerase-independent telomere maintenance mechanism. ALT offers interesting therapeutic perspectives but lacks any… Expand