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BACKGROUND AND PURPOSE The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator-independent ultrasound device in(More)
BACKGROUND AND PURPOSE Enrollment into acute stroke clinical trials is limited to experienced tertiary centers with emergency research infrastructure. Feasibility of remote enrollment via telemedicine into an acute thrombolytic clinical trial has never been demonstrated. METHODS Using telemedicine, our hub stroke research center partnered with two spoke(More)
BACKGROUND We describe innovations in the study design and the efficient data coordination of a randomized multicenter trial of Argatroban in Combination with Recombinant Tissue Plasminogen Activator for Acute Stroke (ARTSS-2). METHODS ARTSS-2 is a 3-arm, multisite/multiregional randomized controlled trials (RCTs) of two doses of Argatroban injection(More)
esearch into treatments for acute strokes has dramatically increased in the last decade. Accordingly, the need for testing through randomized clinical trials has also increased. Because of the unique combination of factors that are common in acute stroke–related research, including narrow treatment windows, ethical concerns regarding research with acute(More)
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