Hari Indupuru

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BACKGROUND AND PURPOSE Enrollment into acute stroke clinical trials is limited to experienced tertiary centers with emergency research infrastructure. Feasibility of remote enrollment via telemedicine into an acute thrombolytic clinical trial has never been demonstrated. METHODS Using telemedicine, our hub stroke research center partnered with two spoke(More)
BACKGROUND AND PURPOSE The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator-independent ultrasound device in(More)
BACKGROUND We describe innovations in the study design and the efficient data coordination of a randomized multicenter trial of Argatroban in Combination with Recombinant Tissue Plasminogen Activator for Acute Stroke (ARTSS-2). METHODS ARTSS-2 is a 3-arm, multisite/multiregional randomized controlled trials (RCTs) of two doses of Argatroban injection(More)
This was a prospective, pilot study of 3 different capacity evaluations (ACE performed by a trained rater, psychiatrist assessment, and neuropsychologist assessment). All assessments were performed independently within the same day or within ±24 hours. All patients were hospitalized patients in stroke, rehabilitation, or neurological Comparison Between a(More)
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