Hardy Kremer

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In today’s applications, massive, evolving data streams are ubiquitous. Massive Online Analysis (MOA) is a software environment for implementing algorithms and running experiments for online learning from evolving data streams. MOA is designed to deal with the challenging problems of scaling up the implementation of state of the art algorithms to real world(More)
Usher syndrome type I is characterized by congenital hearing loss, retinitis pigmentosa (RP), and variable vestibular areflexia. Usher syndrome type ID, one of seven Usher syndrome type I genetic localizations, have been mapped to a chromosomal interval that overlaps with a nonsyndromic-deafness localization, DFNB12. Mutations in CDH23, a gene that encodes(More)
Eleven affected members of a large German-American family segregating recessively inherited, congenital, non-syndromic sensorineural hearing loss (SNHL) were found to be homozygous for the common 35delG mutation of GJB2, the gene encoding the gap junction protein Connexin 26. Surprisingly, four additional family members with bilateral profound SNHL carried(More)
Cowden disease, also known as multiple hamartoma syndrome, is an autosomal dominant cancer syndrome with a high risk of breast and thyroid cancer. The gene involved has been localized to chromosome 10q22-23. Recently, the tumour suppressor gene PTEN/MMAC1, encoding a putative protein tyrosine or dual-specificity phosphatase, was cloned from that region and(More)
Time series arise in many different applications in the form of sensor data, stocks data, videos, and other time-related information. Analysis of this data typically requires searching for similar time series in a database. Dynamic Time Warping (DTW) is a widely used high-quality distance measure for time series. As DTW is computationally expensive,(More)
In today's applications, evolving data streams are ubiquitous. Stream clustering algorithms were introduced to gain useful knowledge from these streams in real-time. The quality of the obtained clusterings, i.e. how good they reflect the data, can be assessed by evaluation measures. A multitude of stream clustering algorithms and evaluation measures for(More)
Mutations in the transmembrane channel-like gene 1 (TMC1) cause prelingual autosomal recessive (DFNB7/11) and postlingual progressive autosomal dominant (DFNA36) nonsyndromic hearing loss. To determine the genetic causes of autosomal recessive nonsyndromic hearing loss (ARNSHL) in the northeast and east of Turkey, 65 unrelated families without mutations in(More)
OBJECTIVE To describe clinical and radiologic features, results of ear surgery, and genetic analysis in three families with Teunissen-Cremers syndrome. DESIGN Case series. SETTING Tertiary referral center. BACKGROUND The NOG gene encodes the protein noggin, which has antagonist action in osteogenesis. Malformation of bones and joints may result from(More)
Analysis of temporal climate data is an active research area. Advanced data mining methods designed especially for these temporal data support the domain expert’s pursuit to understand phenomena as the climate change, which is crucial for a sustainable world. Important solutions for mining temporal data are cluster tracing approaches, which are used to mine(More)