Harash K Narang

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Intracerebral inoculation of newborn and 5-week-old mice with Zika virus resulted in an early and marked enlargement of astroglial cells with patchy destruction of the pyriform cells of Ammon's horn. Replication of the virus was demonstrated in both neurones and astroglial cells. New virions appeared to be formed within networks of endoplasmic reticulum.(More)
Detailed electron microscopic study of cerebellum and medulla of sheepaffected with natural scrapie is reported. Two types of virus-like particles, non-membrane bound and membrane bound occur in neurons, pre-synaptic terminals and axis cylinders. The latter type were seen being apparently formed at the plasma membranes. Their size corresponds with that(More)
The cucumber- or sausage-shaped particles described before in scrapie rat and natural scrapie sheep are also found in scrapie mouse with the use of ruthenium red and lanthanum nitrate. It is suggested that they have a nucleic acid core surrounded by a coat of acid polysaccharide. The plasma membranes are pair of unit membranes.
In an electron microscopic study of brain biopsy material from 6 patients with Creutzfeldt-Jacob disease, virus-like particles resembling herpes have been seen. These particles were found only in reactive astrocytes. In 2 out of 6 Creutzfeldt-Jacob brain biopsies some profiles were filled with tubular structures resembling the nucleocapsid of paramyxovirus.(More)
In four of seven MS brain biopsies (not from the neighbourhood of a lesion) tubular structures resembling the nucleocapsids of a paramyxovirus have been seen sometimes in considerable numbers. They were not seen in non-MS material. Should they turn out to be truly paramyxovirus in origin, the activity of the virus might be direct or indirect in pathogenesis(More)