Harald Wagner

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The inhibition of monoamine oxidase (MAO) by six fractions from hypericum extract and three characteristic constituents (as pure substances) were analyzed in vitro and ex vivo to study the antidepressive mechanism of action. Rat brain homogenates were used as the in vitro model, while the ex vivo analysis was performed after intraperitoneal application of(More)
The isolated retina of rabbit lies on nylon tissue fixed in a ring, which is placed in a chamber. The lower side of the retina, by choice the receptor or ganglion cell side, is superfused by a plasma saline mixture kept at 35 degrees C. At the upper side of the retina, warm humidified oxygen is added. The two sides are isolated from each other by a rubber(More)
Hypericum extracts contain at least ten constituents or groups of components that may contribute to the pharmacological effects. It is not yet possible to correlate the antidepressive mode of action with specific constituents; therefore, the pharmaceutical quality of the extracts was characterized on the basis of typical leading substances and especially(More)
Over the last few years our group has been strongly involved in the study of the chemistry of oligosilanes. 1,2 In particular, the development of a convenient synthetic access to structurally diverse oligosilanyl anions 3À6 allowed the preparation of a huge variety of previously unknown small polysilanes. Some 40 years ago Ishikawa and Kumada discovered the(More)
b S Supporting Information ' INTRODUCTION In recent years small alkylated polysilanes 1 have been used to investigate the conformational dependency of the σ-bond electron delocalization of these compounds. 2À8 Some reports have dealt with branched derivatives of this substance class, which were either den-drimers 9À14 or linear silanes with branched end(More)
The receptor potential of the isolated rabbit retina was recorded between a microelectrode approximately 80 microns deep from the inner limiting membrane and a reference electrode at the receptor side. Amplitude and slope of the receptor potential and the area under it were measured as a function of increasing stimulus intensity and the amplitude and(More)
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