Harald W. Platta

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Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import.

Harald W. Platta, Fouzi El Magraoui, Bastian E. Baeumer, Daniel Schlee, Wolfgang Girzalsky, Ralf Erdmann
Molecular and cellular biology
2009

The PTS1-dependent peroxisomal matrix protein import is facilitated by the receptor protein Pex5 and can be divided into cargo recognition in the cytosol, membrane docking of the cargo-receptor… (More)

Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol

Harald W. Platta, Silke D Grunau, Katja Rosenkranz, Wolfgang Girzalsky, Ralf Erdmann
Nature Cell Biology
2005

Peroxisomal import receptors bind their cargo proteins in the cytosol and target them to docking and translocation machinery at the peroxisomal membrane (reviewed in ref. 1). The receptors release… (More)

Ubiquitination of the peroxisomal import receptor Pex5p.

Harald W. Platta, Wolfgang Girzalsky, Ralf Erdmann
The Biochemical journal
2004

Proteins harbouring a peroxisomal targeting signal of type 1 (PTS1) are recognized by the import receptor Pex5p in the cytosol which directs them to a docking and translocation complex at the… (More)

Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling

Harald W. Platta, Fouzi El Magraoui, Daniel Schlee, Silke D Grunau, Wolfgang Girzalsky, Ralf Erdmann
The Journal of cell biology
2007

Pex5p, which is the import receptor for peroxisomal matrix proteins harboring a type I signal sequence (PTS1), is mono- and polyubiquitinated in Saccharomyces cerevisiae. We identified Pex5p as a… (More)

Endocytosis and signaling.

Harald W. Platta, Harald Stenmark
Current opinion in cell biology
2011

Many cellular signaling processes are governed by endocytosis through the internalization of plasma membrane receptors. This receptor clearance defines the quality with which a cell can react to… (More)

Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery.

Mykhaylo O. Debelyy, Harald W. Platta, +6 authors Ralf Erdmann
The Journal of biological chemistry
2011

Peroxisomal matrix protein import is facilitated by cycling receptors shuttling between the cytosol and the peroxisomal membrane. One crucial step in this cycle is the ATP-dependent release of the… (More)

The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae.

Immanuel Grimm, Delia Saffian, Harald W. Platta, Ralf Erdmann
Biochimica et biophysica acta
2012

The recognition of the conserved ATP-binding domains of Pex1p, p97 and NSF led to the discovery of the family of AAA-type ATPases. The biogenesis of peroxisomes critically depends on the function of… (More)

Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal membrane.

Astrid Hensel, Sabrina Beck, Fouzi El Magraoui, Harald W. Platta, Wolfgang Girzalsky, Ralf Erdmann
The Journal of biological chemistry
2011

The peroxisomal matrix protein import is facilitated by cycling receptor molecules that shuttle between the cytosol and the peroxisomal membrane. In the yeast Saccharomyces cerevisiae, the import of… (More)

Import of proteins into the peroxisomal matrix

Sohel Hasan, Harald W. Platta, Ralf Erdmann
Front. Physiol.
2013

Peroxisomes constitute a dynamic compartment in all nucleated cells. They fulfill diverse metabolic tasks in response to environmental changes and cellular demands. This adaptation is implemented by… (More)

The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion.

Nina Marie Pedersen, Camilla Raiborg, +5 authors Harald Stenmark
Traffic
2012

Phosphatidylinositol 3-phosphate (PtdIns3P) orchestrates endosomal cargo transport, fusion and motility by recruiting FYVE or PX domain-containing effector proteins to endosomal membranes. In an… (More)

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