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The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1
The molecular details of glycolipid presentation by CD1 antigen-presenting molecules are well studied in mammalian systems. However, little is known about how these non-classical MHC class I (MHCI)Expand
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Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire
Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal. Based on growing evidenceExpand
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Unusual Armadillo Fold in the Human General Vesicular Transport Factor p115
The golgin family gives identity and structure to the Golgi apparatus and is part of a complex protein network at the Golgi membrane. The golgin p115 is targeted by the GTPase Rab1a, contains a largeExpand
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A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR
Today's proteome is the result of innumerous gene duplication, mutagenesis, drift and selection processes. Whereas random mutagenesis introduces predominantly only gradual changes in proteinExpand
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Armadillo Motifs Involved in Vesicular Transport
Armadillo (ARM) repeat proteins function in various cellular processes including vesicular transport and membrane tethering. They contain an imperfect repeating sequence motif that forms a conservedExpand
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Overview on the Systematics of Biotoxins as Threat Agents
Biological threat agents are usually considered as pathogens like bacteria or viruses that can be used to harm people, animals or plants. But these agents also include a very special group of agentsExpand