Harald Hofmann

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Hospital information systems are state of the art nowadays. Therefore, Digital Pathology, also labelled as Virtual Microscopy, has gained increased attention. Triggered by radiology, standardized information models and workflows were world-wide defined based on DICOM. However, DICOM-conform integration of Digital Pathology into existing clinical information(More)
The use of lossy compression in medical imaging is controversial, although it is inevitable to reduce large data amounts. In contrast with lossy compression, lossless compression does not impair image quality. In addition to our previous studies, we evaluated virtual 3-dimensional microscopy using JPEG2000 whole slide images of gastric biopsy specimens with(More)
To reproduce focusing in virtual microscopy, it is necessary to construct 3-dimensional (3D) virtual slides composed of whole slide images with different focuses. As focusing is frequently used for the assessment of Helicobacter pylori colonization in diagnostic pathology, we prepared virtual 3D slides with up to 9 focus planes from 144 gastric biopsy(More)
Data compression is inevitable to reduce the huge data amounts of virtual slides, especially in virtual 3-dimensional (3D) microscopy. Lossy compression influences the image quality and leads to recognizable compression artifacts above a compression ratio of 20:1 in JPEG2000 format. To test out whether higher compression ratios are acceptable in diagnostic(More)
Picture archiving and communication systems have been widely used in radiology thus far. Owing to the progress made in digital photo technology, their use in medicine opens up further opportunities. In the field of pathology, digital imaging offers new possiblities for the documentation of macroscopic and microscopic findings. Digital imaging has the(More)
Information systems (IS) are well established in the multitude of departments and practices of pathology. Apart from being a collection of doctor's reports, IS can be used to organize and evaluate workflow processes. We report on such a digital workflow management using IS at the Department of Pathology, University Hospital Magdeburg, Germany, and present(More)
Virtual three-dimensional (3D) specimens correspond to 3D visualizations of real pathological specimens on a computer display. We describe a simple method for the digitalization of such specimens from high-quality digital images. The images were taken during a whole rotation of a specimen, and merged together into a JPEG2000 multi-document file. The files(More)