Harald Graber

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A study was undertaken to define the mode of inheritance of idiopathic epilepsy in Labrador retrievers in Switzerland. Seven hundred and ninety-two pedigree certificates from a population of healthy and epileptic dogs from 11 generations were evaluated. Forty-four different families (giving a total of 55 epileptic dogs) were included. Most patients showed(More)
At weaning most of the alveolar epithelial cells in the mammary gland die by apoptosis and are removed by phagocytosis. Caspases are a family of aspartate specific cysteine proteases. Activation of caspases is generally thought to represent a major and irreversible event in the apoptotic process. We analyzed caspase expression and activation during mammary(More)
The effect of multiple-dose ciprofloxacin on antipyrine metabolism was studied in patients suffering from bacterial infections. The patients were given antipyrine 15 mg/kg intravenously before and after ciprofloxacin treatment. The dosage of ciprofloxacin was 500 mg bd by mouth for 8-10 days. Blood samples were taken at 0, 2, 4, 6, 10 h. Antipyrine total(More)
This study was undertaken to determine the effect of age on the pharmacokinetics of cefotaxime and desacetylcefotaxime after intravenous administration of 1 g cefotaxime. 30 elderly patients suffering from acute infection were enrolled in the study. They were divided into 3 subgroups (group I aged 60 to 70 years, group II aged 71 to 80 years, group III aged(More)
Antibiotic serum levels were recorded from 100 patients with burns. Antibiotic doses to ensure effective serum levels were found to be in excess of maximum values quoted as necessary by manufacturers, provided that serum creatinine was normal. These findings were in agreement with literature data. This was the first instance to check on serum levels,(More)