Harald Braun

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House dust mite (HDM) is one of the most common allergens worldwide. In this study, we have addressed the involvement of IL-1 in the interaction between HDM and the innate immune response driven by lung epithelial cells (ECs) and dendritic cells (DCs) that leads to asthma. Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, failed to(More)
OBJECTIVES Attenuation correction of positron emission tomographic (PET) data is critical in providing accurate and quantitative PET volumes. Deriving an attenuation map (μ-map) from magnetic resonance (MR) volumes is a challenge in PET/MR hybrid imaging. The difficulty lies in differentiating cortical bone from air from standard MR sequences because both(More)
PURPOSE In simultaneous positron emission tomography/magnetic resonance (PET/MR) imaging, local receiver surface radiofrequency (RF) coils are positioned in the field-of-view (FOV) of the PET detector during PET/MR data acquisition and potentially attenuate the PET signal. For flexible body RF surface coils placed on top of the patient's body, MR-based(More)
PURPOSE Flexible radiofrequency (RF) surface coils used in simultaneous PET/MR imaging are currently disregarded in PET attenuation correction (AC) since their position and individual geometry are unknown in whole-body patient scans. The attenuation of PET emission data due to the presence of RF surface coils has been investigated by several research groups(More)
PURPOSE In quantitative PET imaging, it is critical to accurately measure and compensate for the attenuation of the photons absorbed in the tissue. While in PET/CT the linear attenuation coefficients can be easily determined from a low-dose CT-based transmission scan, in whole-body MR/PET the computation of the linear attenuation coefficients is based on(More)
PURPOSE With the recent introduction of integrated whole-body hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) scanners, the need for data collection strategies arises that provide time efficient, simultaneous, and easy acquisition of PET and MRI data. One approach is to develop acquisition protocols with continuous table motion. In(More)
Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer.(More)
BACKGROUND In integrated PET/MR hybrid imaging the evaluation of PET performance characteristics according to the NEMA standard NU 2-2007 is challenging because of incomplete MR-based attenuation correction (AC) for phantom imaging. In this study, a strategy for CT-based AC of the NEMA image quality (IQ) phantom is assessed. The method is systematically(More)
UNLABELLED In current PET/MR systems, the data acquisition paradigm is based on a multistation examination, imaging the patient from hip to head. This strategy has potential limitations, especially in terms of workflow and PET acquisition efficiency. In this work, the technical implementation of simultaneous PET and MR data acquisition with continuous table(More)