Haralambos Hatzikirou

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Human beings are thought to be unique amongst the primates in their capacity to produce rapid changes in the shape of their vocal tracts during speech production. Acoustically, vocal tracts act as resonance chambers, whose geometry determines the position and bandwidth of the formants. Formants provide the acoustic basis for vowels, which enable speakers to(More)
Studying the emergence of invasiveness in tumours using game theory EPJ manuscript No. the date of receipt and acceptance should be inserted later Abstract. Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is increased motility which is needed for invasion of other tissues and(More)
Tumour cells show a varying susceptibility to radiation damage as a function of the current cell cycle phase. While this sensitivity is averaged out in an unperturbed tumour due to unsynchronised cell cycle progression, external stimuli such as radiation or drug doses can induce a resynchronisation of the cell cycle and consequently induce a collective(More)
Tumor cells develop different strategies to cope with changing microenvironmental conditions. A prominent example is the adaptive phenotypic switching between cell migration and proliferation. While it has been shown that the migration-proliferation plasticity influences tumor spread, it remains unclear how this particular phenotypic plasticity affects(More)
Biological organisms are complex systems characterized by collective behavior emerging out of the interaction of a large number of components (molecules and cells). In complex systems, even if the basic and local interactions are perfectly known, it is possible that the global (collective) behavior obeys new laws that are not obviously extrapolated from the(More)
Multipotent differentiation, where cells adopt one of several cell fates, is a determinate and orchestrated procedure that often incorporates stochastic mechanisms in order to diversify cell types. How these stochastic phenomena interact to govern cell fate is poorly understood. Nonetheless, cell fate decision-making procedure is mainly regulated through(More)
Inspired by the parallels between information coding in morphogenesis and information coding in computer communication, we introduce a new model for coupled discrete memoryless channels in which the error probability of one channel depends on the output of the other channel. The model is motivated by a type of cell-cell communication. It is shown that(More)