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Ataxia and Male Sterility (AMS) Mutant Mouse. An Analysis of the ams Mutation and the Different Types of Cell Death Affected by this Mutation
The Ataxia and Male Sterility (AMS) mouse is a mutant that exhibits ataxia due to a near-complete loss of the cerebellar Purkinje cells and male sterility because of severe oligospermia due to theExpand
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K 1115 A , a New Anthraquinone Derivative that Inhibits the Binding of Activator Protein-1 ( AP-1 ) to its Recognition Sites
  • Masa-aki, MASEGI, +6 authors NOBUAKI NARUSE Eisai
  • 2008
Activator protein-1 (AP-1) was first identified as a nuclear factor that activates the expression of the human metallothionein IIa promoter1), and is now known to be a critical transcriptional factorExpand
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Use of Blocking Antibodies as Probes for in Vivo Functions of Chemokines
Leukocyte infiltration into an inflammatory site is one of the pathological hallmarks of inflammatory reaction. Locally produced chemotactic factors are presumed to mediate the sequence of eventsExpand
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Responses of Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood Mononuclear Cells to Alloantigen Stimulation
To the Editor: We have been much interested in the recent report by Mielcarek et al[1][1] that proposed one of the mechanisms explaining the unexpectedly low incidence of acute graft-versus-hostExpand
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The 21st Annual Meeting of the Society for Hard Tissue Regenerative Biology The 21st Annual Meeting of the Society for Hard Tissue Regenerative Biology Period: August 25, 2012 Venue: School of
Induced pluripotent stem (iPS) cells can be generated through the reprogramming of somatic cells by forced expression of defined exogenous factors. We previously reported that the gingiva, which isExpand
Single-molecule detection of hotspots for dynamic concentration of the kappa opioid receptor
The kappa opioid receptor (kOR), a G-protein-coupled receptor, was expressed in the plasma membrane (PM) of cultured cells and observed at the single-molecule level. The kOR molecules underwentExpand
Role in Tumor Suppression Antioncogenic Transcription Factor , IRF-1 , and Its Possible Gene as a Target of the Lysyl Oxidase Identification of the Updated Version
The transcriptional activator IFN regulatory factor 1 (IRF-1) and its antagonistic represser IRF-2 are regulators of the IFN system. IRF-1 also manifests tumor suppressive activity, and itsExpand
Studying Human Leukemic Stem Cells in Mice
Transplantation of human leukemic cells into severe combined immunodeficiency(SCID)mice has been attempted to study leukemogenesis and to develop therapeuticmodalities.Previous models,however,wereExpand