Haotian Wu

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Male germ cells require multiple epigenetic reprogramming events during their lifespan to achieve reproductive capacity. An emerging body of compelling data demonstrates that environmental exposures can be embodied within the developing male germ cell as epigenetic marks. In turn, these epigenetic marks can impart information at fertilization to affect the(More)
Akt2 overexpression correlates with chemoresistance of colorectal cancer (CRC). However, the cellular functions and precise signals elicited by Akt2 in LSCC have not been elucidated. Here, we transfected a CRC cell line HCT116 with Akt-2 targeted shRNA in order to establish a cell line with Akt2 knockdown. In vitro experiments showed that knockdown Akt2 in(More)
In each dimension N ≥ 3 and for each real number λ ≥ 1, we construct a family of complete rotationally symmetric solutions to Ricci flow on R N which encounter a global singularity at a finite time T. The singularity forms arbitrarily slowly with the curvature blowing up arbitrarily fast at the rate (T − t) −(λ+1). Near the origin, blow-ups of such a(More)
For n + 1 ≥ 3, we construct complete solutions to Ricci flow on R n+1 which encounter global singularities at a finite time T. The singularities are forming arbitrarily slowly with the curvature blowing up arbitrarily fast at the rate (T − t) −2λ for λ ≥ 1. Near the origin, blow-ups of such a solution converge uniformly to the Bryant soliton. Near spatial(More)
A series of new 16E-arylidene androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activities against the human cancer cell lines SW480, A549, HepG2 and HeLa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 μM(More)
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