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This retrospective study evaluated the diagnostic value of integrated whole-body 18F-fluorodeoxyglucose positron-emission tomography and computed tomography (18F-FDG-PET/CT) in early detection of second primary malignancies in cancer patients. From June 2007 to October 2008, 677 cancer patients who had undergone a whole-body 18F-FDG-PET/CT imaging for the(More)
OBJECTIVE Increased expression of sodium/iodide symporter (NIS) is required for reporter gene imaging and effective radioiodine treatment of tumor. We investigated whether increased accumulation of iodine can be induced by sodium butyrate through a newly developed baculoviral transfer of the human NIS (hNIS) gene in A549 human lung adenocarcinoma. METHODS(More)
OBJECTIVE Radioiodine ablation is ineffective in patients with radioiodine nonresponsive thyroid carcinoma. We investigated the effects of all-trans retinoic acid (ATRA) combined with histone deacetylase inhibitor, tributyrin on sodium-iodide symporter (NIS) expression, radioiodine uptake, and inhibition of cell proliferation in a poorly differentiated(More)
OBJECTIVE To explore the combined anti-tumor effect of radiation therapy and gene-targeted suppression of tumor neovasculature in lung adenocarcinoma in vivo, and to explore the feasibility of micro-PET/CT in dynamic evaluation of treatment effectiveness. METHODS Thirty 5-6-week old male BALB/c nude mice were used in this study. The mouse models of(More)
OBJECTIVE Increased expression of sodium iodide symporter (NIS) is required for reporter gene imaging and effective radioiodine treatment of tumor. As the early-growth response-1 (Egr1) promoter is activated by radioisotopes, the existence of a positive feedback effect of I-promoted Egr1-hNIS expression is possible. Compared with a widely used(More)
PURPOSE As intracellular iodine is released rapidly, increased expression of sodium/iodide symporter (NIS) is required for effective radioiodine treatment of tumor. As Egr1 promoter is activated by ¹³¹I and may promote human NIS (hNIS) expression, hNIS also induces ¹³¹I uptake and activates Egr1, so the existence of a positive feedback effect of(More)
The role of (18)F-Flurodeoxyglucose positron emission tomography ((18)F-FDG PET) scan in localization of ectopic Cushing's syndrome (EAS) tumor is still controversial. Here, we report on the use of integrated (18)F-FDG PET and computed tomography ((18)F-FDG PET/CT) in localization of EAS tumors in patients with ectopic Cushing's syndrome. Five patients,(More)
The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidine in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in terms of preparation, viscosity and in vitro release. The viscosity of the gellan gum formulations in(More)
UNLABELLED The first aim of our study was to compare the role of (18)F-FDG PET/CT with that of CT alone in detecting the primary cause of ascites. A secondary aim was to compare the value of (18)F-FDG PET/CT with that of CT alone in detecting abdominal cavity metastasis. Finally, we analyzed the receiver-operating-characteristic (ROC) curves of maximal(More)
The aim of this study to develop galactosylated erlotinib liposomes for treatment of lung cancer. The liposomes were prepared by using solvent evaporation method. Various parameters such as particle size, zeta potential, entrapment efficiency, stability and in vitro drug release were determined. The size of liposomes (both conventional and modified) was(More)