Haoliang Yuan

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The choice of the over-complete dictionary that sparsely represents data is of prime importance for sparse coding-based image super-resolution. Sparse coding is a typical unsupervised learning method to generate an over-complete dictionary. However, most of the sparse coding methods for image super-resolution fail to simultaneously consider the geometrical(More)
many denoising algorithms [1, 2] work on image patches, so it is useful to formulate a patch-based image model = = + + , (1) where is the original patch intensity written in a vectorized form, is the vectorized noisy image patch and is a vectorized noise patch. Our goal is to design a denoising algorithm which can remove the noise from. This paper presents(More)
In recent years, various virtual screening (VS) tools have been developed, and many successful screening campaigns have been showcased. However, whether by conventional molecular docking or pharmacophore screening, the selection of virtual hits is based on the ranking of compounds by scoring functions or fit values, which remains the bottleneck of VS due to(More)
Fragment-based drug design (FBDD) is considered a promising approach in lead discovery. However, for a practical application of this approach, problems remain to be solved. Hence, a novel practical strategy for three-dimensional lead discovery is presented in this work. Diverse fragments with spatial positions and orientations retained in separately(More)
c-Met has been considered as an attractive target for developing antitumor agents. The highly selective c-Met inhibitors provide invaluable opportunities for the combination with other therapies safely to achieve the optimal efficacy. In this work, a series of triazolopyrazine c-Met inhibitors with exquisitely selectivity were investigated using a(More)