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Innate immune responses of a lepidopteran insect, Manduca sexta
Current research is focused on the proteolytic activation of prophenoloxidase (proPO) – a reaction implicated in melanotic encapsulation, wound healing, and protein cross‐linking, and three proPO‐activating proteinases, each of which requires serine proteinase homologs as a cofactor for generating active phenol oxidase. Expand
Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions, suggesting how innate immunity may have evolved. Expand
The genome of the model beetle and pest Tribolium castaneum
Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agriculturalExpand
Comparative genomic analysis of the Tribolium immune system
A framework of information on Tribolium immunity is established, which may serve as a stepping stone for future genetic analyses of defense responses in a nondrosophiline genetic model insect. Expand
A serpin mutant links Toll activation to melanization in the host defence of Drosophila
Evidence is presented for the coordination of hemolymph‐borne melanization with activation of the Toll pathway in the Drosophila host defence and it is shown that flies deficient for this serpin exhibit spontaneous melanization in larvae and adults. Expand
Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships.
A framework of information about evolutionary relationships among the Drosophila SPs and SPHs is established, which may facilitate research on these proteins as well as homologous molecules from other invertebrate species. Expand
CoilDesigner: a general-purpose simulation and design tool for air-to-refrigerant heat exchangers
Object-oriented programming techniques were applied in developing the program to facilitate a modular, highly flexible and customizable design platform and in building a graphic user-friendly interface. Expand
Insights into social insects from the genome of the honeybee Apis mellifera
The genome sequence of the honeybee Apis mellifera is reported, suggesting a novel African origin for the species A. melliferA and insights into whether Africanized bees spread throughout the New World via hybridization or displacement. Expand
Nonproteolytic serine proteinase homologs are involved in prophenoloxidase activation in the tobacco hornworm, Manduca sexta.
In insects, the prophenoloxidase activation system is a defense mechanism against parasites and pathogens. Recognition of parasites or pathogens by pattern recognition receptors triggers activationExpand
Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs.
Purification, characterization, and regulation of PAP-3 from the hemolymph indicate that proPO activation by PAPs is a tightly regulated process, and could play different roles during immune responses and developmental processes. Expand