• Publications
  • Influence
Further studies on mefloquine and praziquantel alone or interaction of both drugs against Schistosoma japonicum in vitro
It was found that when mefloquine combined with praziquantel simultaneously or administered 1 h after addition of prazquantel, the spasmodic contraction of the male worm body was antagonized by me floquine in various degrees according to the concentrations of meflquine used. Expand
Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths
Single-dose tribendimidine showed similar efficacy against C. sinensis as praziquantel with less adverse events, and achieved significantly higher cure rate in the treatment for hookworm than those of prazquantel and mebendazole. Expand
Slow-release praziquantel for dogs: presentation of a new formulation for echinococcosis control
Praziquantel given as an in situ slow-release formulation by subcutaneous injection resulted in concentrations of the active principle in beagle dogs, which should be capable of resisting new Echinococcus infections for at least 6 months. Expand
The control of hookworm infection in China
Although the prevalence of hookworm infection has fallen significantly in the last 15 years in China, the current strategy for controlling hookworm infections still needs to be strengthened along with the three-pronged approach, e.g. distributing anthelmintic drugs in schools and undertaking large-scale ofhookworm deworming, improving water supplies and sanitation, and proper health education. Expand
Research gaps for three main tropical diseases in the People’s Republic of China
These three diseases: schistosomiasis japonica, malaria and echinococcosis are analyzed and it is believed these three diseases can eventually be eliminated in mainland China if all the research gaps are abridged in a short period of time. Expand
One‐pot Synthesis of 2,5‐Disubstituted‐1,3,4‐oxadiazoles Based on the Reaction of N,N‐Dimethyl Amides with Acid Hydrazides
Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodologyExpand
Enhanced bioavailability and cysticidal effect of three mebendazole-oil preparations in mice infected with secondary cysts of Echinococcus granulosus
Three MBZ-oil (OA, GT, and SB) preparations administered orally to mice not only improve the bioavailability of MBZ relative to that ofMBZ suspended in 1 % tragacanth, but their effects against hydatid cysts also significantly enhance. Expand
Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment. Expand
Pharmacophore-Based Virtual Screening Toward the Discovery of Novel Anti-echinococcal Compounds
It is demonstrated that pharmacophore-based virtual screenings with high drug identification efficiency could be used to find novel drugs for treating echinococcosis and selected S6 along with two active amino alcohols for in vivo pharmacodynamic and pharmacokinetic studies. Expand
An alternative mebendazole formulation for cystic echinococcosis: the treatment efficacy, pharmacokinetics and safety in mice
It is shown that MBZ-OS is a promising new formulation of MBZ for treatment of hydatid diseases without showing significantly liver toxicity, and the injury of the liver was not significantly altered by taking MBz-OS compared to the untreated control. Expand