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DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
On the basis of a two-step metallization procedure, the 4 x 4 nanoribbons acted as an excellent scaffold for the production of highly conductive, uniform-width, silver nanowires.
DNA Origami with Complex Curvatures in Three-Dimensional Space
This work presents a strategy to design and construct self-assembling DNA nanostructures that define intricate curved surfaces in three-dimensional (3D) space using the DNA origami folding technique.
Molecular robots guided by prescriptive landscapes
It is demonstrated that previously developed random walkers show elementary robotic behaviour when interacting with a precisely defined environment and single-molecule microscopy observations confirm that such walkers achieve directional movement by sensing and modifying tracks of substrate molecules laid out on a two-dimensional DNA origami landscape.
Designer nanoscale DNA assemblies programmed from the top down
This work presents a general solution to this problem that offers the ability for nonspecialists to design and synthesize nearly arbitrary DNA-based nanoparticles using only a simple surface-based representation of target 3D geometry to automatically generate the ssDNA needed to synthesize the object.
Interenzyme substrate diffusion for an enzyme cascade organized on spatially addressable DNA nanostructures.
- Jinglin Fu, Minghui Liu, Yan Liu, N. Woodbury, Hao Yan
- BiologyJournal of the American Chemical Society
- 16 March 2012
The results suggest that Brownian diffusion of intermediates in solution governed the variations in activity for more distant enzyme pairs, while dimensionally limited diffusion across connected protein surfaces contributed to the enhancement inActivity for closely spaced GOx/HRP assemblies.
Challenges and opportunities for structural DNA nanotechnology.
The technical challenges in the field of structural DNA nanotechnology are examined and some of the promising applications that could be developed if these hurdles can be overcome are outlined.
DNA origami as a carrier for circumvention of drug resistance.
A novel drug carrier system based on self-assembled, spatially addressable DNA origami nanostructures that confronts limitations in biocompatibility and ability to engineer spatially addressed surfaces for multi-functional activity is presented.
Scaffolded DNA origami of a DNA tetrahedron molecular container.
- Yonggang Ke, J. Sharma, Minghui Liu, Kasper Jahn, Yan Liu, Hao Yan
- BiologyNano letters (Print)
- 6 May 2009
A strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces with total external volume and internal cavity about 1.8 x 10(-23) m(3), respectively.
A DNA Nanostructure‐based Biomolecular Probe Carrier Platform for Electrochemical Biosensing
This work devise a new concept to achieve improved probe–target recognition properties by introducing a probe bearing a 3D DNA nanostructure-based chip platform and provides a significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported linear or stem-loop probe structures.
Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm.
It is shown that a DNA nanostructure can be used to create a multi-enzyme complex in which an artificial swinging arm facilitates hydride transfer between two coupled dehydrogenases.