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Diverse exocytic pathways for mast cell mediators.

This review illustrates existing evidence that highlights the diverse exocytic pathways in mast cells and discusses strategies to delineate these pathways so as to identify unique molecular components which could serve as new drug targets for more effective and specific treatments against mast cell-related diseases.
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Biophysical Assessment of Single Cell Cytotoxicity: Diesel Exhaust Particle-Treated Human Aortic Endothelial Cells

Analysis of toxic effects of DEPs on a model cell line from human aortic endothelial cells revealed that DEP intervention would be one cause of vasodilation, which will expand understanding of biophysical aspects associated with DEP cytotoxicity in HAECs.
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Short Term Interactions with Long Term Consequences: Modulation of Chimeric Vessels by Neural Progenitors

It is found that the coculture of neural progenitors with endothelial cells led to the formation of chimeric host-donor vessels, and this suggests that one can modulate the host versus donor contributions using short-term paracrine signaling which has broad implications for the application of engineered microvascular networks and cellular therapy more broadly.
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Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models

It was observed that CEP attenuated lung histopathologic changes and down-regulated the level of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, in the mouse acute lung injury model.
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Drosophila SNAP-29 Is an Essential SNARE That Binds Multiple Proteins Involved in Membrane Traffic

The characterization of the Drosophila homologue of SNAP-29 (dSNAP-29), which is expressed throughout development, is reported, which does not participate in any SDS-resistant complexes, despite its interaction with dsyntaxin1 and dsy syntaxin16 in vitro.
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The Protein Partners of GTP Cyclohydrolase I in Rat Organs

GCH1 interacts with proteins in an organ dependant manner and EIF3I might be a general regulator of GCH1, which indicates G CH1 might have broader functions beyond tetrahydrobiopterin biosynthesis.
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Differential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE Complexes

It is shown for the first time that Munc18a operates synergistically with SNAP-23-based non-neuronal SNARE complexes (i to iv) in lipid mixing, in contrast to Munc 18b and c, which exhibit no positive effect on any SNARE combination tested.
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Anion Exchange HPLC Isolation of High-Density Lipoprotein (HDL) and On-Line Estimation of Proinflammatory HDL

Proinflammatory high-density lipoprotein (p-HDL) is a biomarker of cardiovascular disease. Sickle cell disease (SCD) is characterized by chronic states of oxidative stress that many consider to play…
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PKC-dependent phosphorylation of Munc18a at Ser313 in activated RBL-2H3 cells

This study shows for the first time that PKC inhibitor Ro-03-0432, which inhibits RBL-2H3 exocytosis/degranulation in a concentration-dependent fashion, prevents the phosphorylation of membrane fusion factor Munc18a at Ser 313.
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Identification of proteins interacting with GTP cyclohydrolase I

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