Hao-Wei Su

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Dielectrophoresis-based cell separation has significant promise for separation of cells from heterogeneous mixtures based on their electrical properties and is used in diverse areas ranging from hematopoietic stem cell purification to cancer cell isolation. The electrical properties of cells in heterogeneous populations determine if and how well cell(More)
Mechanical phenotyping of single cells is an emerging tool for cell classification, enabling assessment of effective parameters relating to cells' interior molecular content and structure. Here, we present iso-acoustic focusing, an equilibrium method to analyze the effective acoustic impedance of single cells in continuous flow. While flowing through a(More)
We demonstrate an automated high-throughput method—multimodal electrical and optical cytometry (MultiMEOC)—for simultaneously measuring the electrical and optical properties of cells. MultiMEOC utilizes microscopic imaging of particles moving against electrodes to extract the electrical and optical properties on a per-cell basis. We used the method to(More)
Sepsis is a potentially lethal condition that may be ameliorated through early monitoring of circulating activated leukocytes for faster stratification of severity of illness and improved administration of targeted treatment. Characterization of the intrinsic electrical properties of leukocytes is label-free and can provide a quick way to quantify the(More)
Dielectrophoresis-based cell separation has significant promise for separation of cells from heterogeneous mixtures based on their electrical properties and is used in diverse areas ranging from hematopoietic stem cell purification to cancer cell isolation. The electrical properties of cells in heterogeneous populations determine if and how well cell(More)
This thesis describes the development of a rapid dielectrophoretic characterization tool for monitoring leukocyte activation, and its application for monitoring sepsis progression. Sepsis is an uncontrolled activation of the immune system that causes an excessive inflammatory response or an impaired immunity. The unpredictable immune status makes the(More)
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